Anti-GQ1b antibody as a factor predictive of mechanical ventilation in Guillain-Barre syndrome
Anti-GQ1b antibody as a factor predictive of mechanical ventilation in Guillain-Barre syndrome
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DOI：
10.1212/01.wnl.0000113718.27729.43
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发表时间：
2004-03-09
期刊：
影响因子：
9.9
通讯作者：
Kanazawa, I
中科院分区：
文献类型：
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作者：
Kaida, K;Kusunoki, S;Kanazawa, I
与87例未通气的格林-巴利综合征（GBS）患者相比，44例通气的GBS患者更常见多颅神经受累（91 vs 50%; p < 0.001）和IgG抗GQ 1b抗体（27 vs 8%; p = 0.006）。在无眼轻瘫的GBS患者中，IgG抗GQ 1b抗体的存在与呼吸衰竭相关（12 [3/25] vs 0% [0/67]; p = 0.04）。抗体的存在可能是GBS呼吸衰竭的预测因素。
Compared with 87 unventilated patients with Guillain - Barre syndrome (GBS), 44 ventilated patients with GBS more frequently had multiple cranial nerve involvement ( 91 vs 50%; p < 0.001) and IgG anti-GQ1b antibody ( 27 vs 8%; p = 0.006). In GBS patients without ophthalmoparesis, the presence of IgG anti-GQ1b antibody was associated with respiratory failure ( 12 [3/25] vs 0% [0/67]; p = 0.04). The presence of the antibody may be a factor predictive of respiratory failure in GBS.