Tissue-mimicking phantoms for photoacoustic and ultrasonic imaging.
Tissue-mimicking phantoms for photoacoustic and ultrasonic imaging.
复制标题
模拟图像声和超声成像的组织幻象。
DOI：
10.1364/boe.2.003193
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发表时间：
2011-11-01
影响因子：
3.4
通讯作者：
Emelianov SY
中科院分区：
文献类型：
--
作者：
Cook JR;Bouchard RR;Emelianov SY
在光声（PA）和超声（US）成像中，整体图像质量都受到介质的光学和声学特性的影响，因此，在旋链和临床应用中使用了组合的PA和US（PAUS）成像，可在构建范围内构建phitemitive to selective to Criental contimitive。 optical properties. Forty-micron, spherical silica particles were used to induce acoustic scattering, Intralipid® 20% IV fat emulsion was employed to enhance optical scattering and ultrasonic attenuation, while India Ink, Direct Red 81, and Evans blue dyes were utilized to achieve optical absorption typical of soft tips. The following parameters were then measured in each phantom formula: speed of sound, acoustic attenuation (from 6 to 22 MHz，声学后散射系数（从6到22 MHz），光吸收（从400 nm到1300 nm）和光散射（从400 nm到1300 nm），然后将这些测量结果与相似的测量结果相比，这些测量值是由这些构造的，这是一定的。 Elatin基础近似添加剂。
In both photoacoustic (PA) and ultrasonic (US) imaging, overall image quality is influenced by the optical and acoustical properties of the medium. Consequently, with the increased use of combined PA and US (PAUS) imaging in preclinical and clinical applications, the ability to provide phantoms that are capable of mimicking desired properties of soft tissues is critical. To this end, gelatin-based phantoms were constructed with various additives to provide realistic acoustic and optical properties. Forty-micron, spherical silica particles were used to induce acoustic scattering, Intralipid® 20% IV fat emulsion was employed to enhance optical scattering and ultrasonic attenuation, while India Ink, Direct Red 81, and Evans blue dyes were utilized to achieve optical absorption typical of soft tissues. The following parameters were then measured in each phantom formulation: speed of sound, acoustic attenuation (from 6 to 22 MHz), acoustic backscatter coefficient (from 6 to 22 MHz), optical absorption (from 400 nm to 1300 nm), and optical scattering (from 400 nm to 1300 nm). Results from these measurements were then compared to similar measurements, which are offered by the literature, for various soft tissue types. Based on these comparisons, it was shown that a reasonably accurate tissue-mimicking phantom could be constructed using a gelatin base with the aforementioned additives. Thus, it is possible to construct a phantom that mimics specific tissue acoustical and/or optical properties for the purpose of PAUS imaging studies.