Analysis of the developing Xenopus tail bud reveals separate phases of gene expression during determination and outgrowth
Analysis of the developing Xenopus tail bud reveals separate phases of gene expression during determination and outgrowth
复制标题
DOI：
10.1016/s0925-4773(98)00015-x
复制
发表时间：
1998-03-01
影响因子：
2.6
通讯作者：
Slack, JMW
中科院分区：
文献类型：
--
作者：
Beck, CW;Slack, JMW
我们研究了非洲爪蟾尾巴的发展，从原肠胚形成结束到在尾芽阶段开始生长。我们发现，早期组的基因表达的阶段，尾芽的决定，在原肠胚形成结束，和后期组的表达在第27期左右，就在尾芽长出。这些基因共同定义了尾芽开始生长时的七个不同区域。我们以前已经表明，尾芽的形成取决于三个组织区域的相互作用，称为N，M和C，在第13阶段。在这里，我们表明，表达的后期组的基因是依赖于这种NMC的相互作用。我们描述的分子相关的两个这些地区，M和C，这是以前无法观察到的，其存在是从胚胎学实验推断。(C)1998爱思唯尔科学爱尔兰有限公司
We have studied Xenopus tail development from the end of gastrulation to the commencement of outgrowth at the tail bud stage. We show that an early group of genes are expressed at the stage of tail bud determination, at the end of gastrulation, and a late group are expressed at around stage 27 just before tail bud outgrowth. Together, these genes define seven distinct regions of the tail bud as outgrowth commences. We have previously shown that formation of a tail bud depends on the interaction of three tissue regions, called N, M and C, at stage 13. Here we show that expression of the late group of genes is dependent on this NMC interaction. We describe molecular correlates of two of these regions, M and C, which were formerly unobservable and whose existence was inferred from embryological experiments. (C) 1998 Elsevier Science Ireland Ltd.