Wearable Cortisol Aptasensor for Simple and Rapid Real-Time Monitoring
Wearable Cortisol Aptasensor for Simple and Rapid Real-Time Monitoring
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DOI：
10.1021/acssensors.1c01734
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发表时间：
2022-01-07
期刊：
影响因子：
8.9
通讯作者：
Kwon, Oh Seok
中科院分区：
文献类型：
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作者：
An, Jai Eun;Kim, Kyung Ho;Kwon, Oh Seok
随着世界面临不同类型的压力，包括2019冠状病毒病（COVID-19）大流行的程度，管理压力水平的必要性变得越来越明显。皮质醇是一种临床证实的与抑郁和焦虑有关的应激激素，会影响个体的身心健康。然而，目前的皮质醇监测方法需要专业人员、大型复杂的机器和长时间的数据分析。在这里，我们提出了一个灵活的和可穿戴的皮质醇aptasensor简单，快速的皮质醇实时监测。通过静电纺丝导电聚丙烯腈（PAN）纳米纤维（NF）和随后的气相沉积羧基化聚（3，4-乙撑二氧噻吩）（PEDOT）的传感通道。皮质醇适体在PEDOT-PAN NF上的缀合为靶分子提供了关键的传感机制。在聚酯（聚对苯二甲酸乙二醇酯）上用液体离子门控场效应晶体管（FET）进行传感测试。传感器性能显示出10 pM的检测限（
The necessity of managing stress levels is becoming increasingly apparent as the world suffers from different kinds of stresses including the extent of pandemic, the corona virus disease 2019 (COVID-19). Cortisol, a clinically confirmed stress hormone related to depression and anxiety, affects individuals mentally and physically. However, current cortisol monitoring methods require expert personnel, large and complex machines, and long time for data analysis. Here, we present a flexible and wearable cortisol aptasensor for simple and rapid cortisol real-time monitoring. The sensing channel was produced by electrospinning conducting polyacrylonitrile (PAN) nanofibers (NFs) and subsequent vapor deposition of carboxylated poly(3,4-ethylenedioxythiophene) (PEDOT). The conjugation of the cortisol aptamer on the PEDOT-PAN NFs provided the critical sensing mechanism for the target molecule. The sensing test was performed with a liquid-ion gated field-effect transistor (FET) on a polyester (polyethylene terepthalate). The sensor performance showed a detection limit of 10 pM (