ARFI IMAGING FOR NONINVASIVE MATERIAL CHARACTERIZATION OF ATHEROSCLEROSIS PART II: TOWARD IN VIVO CHARACTERIZATION
ARFI IMAGING FOR NONINVASIVE MATERIAL CHARACTERIZATION OF ATHEROSCLEROSIS PART II: TOWARD IN VIVO CHARACTERIZATION
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DOI：
10.1016/j.ultrasmedbio.2008.08.015
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发表时间：
2009-02-01
影响因子：
2.9
通讯作者：
Gallippi, Caterina M.
中科院分区：
文献类型：
--
作者：
Behler, Russell H.;Nichols, Timothy C.;Gallippi, Caterina M.
70%的心血管疾病(CVD)死亡归因于动脉粥样硬化。尽管非狭窄动脉粥样硬化斑块具有临床意义，但传统的动脉粥样硬化成像方法并不能有效地检测到它们。此外，传统的成像方法不足以描述与心血管风险评估相关的斑块成分。需要能够改进斑块检测和心血管风险分层的动脉粥样硬化成像技术。声辐射力脉冲(ARFI)超声是一种新的非侵入性区分组织力学性质的成像方法，在这项初步研究中，它被用于体内检测非狭窄斑块和斑块材料评估。在体内对四条髂动脉进行了ARFI成像：(1)没有动脉粥样硬化的正常胆固醇血症猪作为对照，(2)有弥漫性动脉粥样硬化的家族性高胆固醇血症猪，(3)有早期动脉粥样硬化斑块的高脂饲料喂养的正常胆固醇血症猪，(4)有弥漫性动脉粥样硬化和微小闭塞斑块的家族性高胆固醇血症猪。将ARFI结果与空间匹配的免疫组织化学结果进行比较，显示弹性蛋白和胶原含量与ARFI衍生的峰值位移和恢复时间参数之间存在相关性。从ARFI诱导的峰值位移恢复得更快，并且在弹性蛋白和胶原含量较高的区域观察到较小的峰值位移。重要的是，在大斑块、高度进化斑块和小斑块中，组织含量和ARFI结果之间的空间相关性是一致的和可观察到的。ARFI成像成功地区分了非狭窄斑块，而传统的B型超声不能。这项工作验证了ARFI成像作为一种非侵入性成像技术在体内检测和评估动脉粥样硬化斑块的潜在相关性。(电子邮件：russbehler@unc.edu)(C)2009年世界医学和生物学超声联合会。
Seventy percent of cardiovascular disease (CVD) deaths are attributed to atherosclerosis. Despite their clinical significance, nonstenotic atherosclerotic plaques are not effectively detected by conventional atherosclerosis imaging methods. Moreover, conventional imaging methods are insufficient for describing plaque composition, which is relevant to cardiovascular risk assessment. Atherosclerosis imaging technologies capable of improving plaque detection and stratifying cardiovascular risk are needed. Acoustic radiation force impulse (ARFI) ultrasound, a novel imaging method for noninvasively differentiating the mechanical properties of tissue, is demonstrated for in vivo detection of nonstenotic plaques and plaque material assessment in this pilot investigation. In vivo ARFI imaging was performed on four iliac arteries: (1) of a normocholesterolemic pig with no atherosclerosis as a control, (2) of a familial hypercholesterolemic pig with diffuse atherosclerosis, (3) of a normocholesterolemic pig fed a high-fat diet with early atherosclerotic plaques and (4) of a familial hypercholesterolemic pig with diffuse atherosclerosis and a small, minimally occlusive plaque. ARFI results were compared with spatially matched immunohistochemistry, showing correlations between elastin and collagen content and ARFI-derived peak displacement and recovery time parameters. Faster recoveries from ARFI-induced peak displacements and smaller peak displacements were observed in areas of higher elastin and collagen content. Importantly, spatial correlations between tissue content and ARFI results were consistent and observable in large and highly evolved as well as small plaques. ARFI imaging successfully distinguished nonstenotic plaques, while conventional B-mode ultrasound did not. This work validates the potential relevance of ARFI imaging as a noninvasive imaging technology for in vivo detection and material assessment of atherosclerotic plaques. (E-mail: russbehler@unc.edu) (c) 2009 World Federation for Ultrasound in Medicine & Biology.