EXTRACELLULAR PURINE NUCLEOSIDES STIMULATE CELL-DIVISION AND MORPHOGENESIS - PATHOLOGICAL AND PHYSIOLOGICAL IMPLICATIONS
EXTRACELLULAR PURINE NUCLEOSIDES STIMULATE CELL-DIVISION AND MORPHOGENESIS - PATHOLOGICAL AND PHYSIOLOGICAL IMPLICATIONS
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DOI：
10.1016/0306-9877(92)90193-g
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发表时间：
1992-04-01
影响因子：
4.7
通讯作者：
TAKHAL, S
中科院分区：
文献类型：
--
作者：
RATHBONE, MP;CHRISTJANSON, L;TAKHAL, S
细胞外嘌呤核苷和核苷酸是普遍存在的，系统发育古老的细胞间信号。嘌呤从缺氧、受损或死亡的细胞中释放出来。嘌呤核苷和核苷酸是几种类型的细胞如成纤维细胞、内皮细胞和神经胶质细胞的有效有丝分裂原。它们还能诱导其他类型的细胞分化。例如，它们与神经生长因子协同作用，刺激嗜铬细胞瘤细胞系（PC12）的神经突生长。我们认为，包括中枢神经系统在内的组织损伤后，嘌呤核苷和核苷酸与其他生长因子协同作用。它们刺激了参与伤口愈合反应的各种细胞类型的增殖和形态变化。在中枢神经系统中，这种反应包括胶质细胞增殖、毛细血管内皮细胞增殖和神经轴突的发芽。由于细胞外嘌呤的许多作用是通过特定的细胞表面受体介导的，因此这一假设具有广泛的药理学意义。
Extracellular purine nucleosides and nucleotides are ubiquitous, phylogenetically ancient, intercellular signals. Purines are released from hypoxic, damaged or dying cells. Purine nucleosides and nucleotides are potent mitogens for several types of cells such as fibroblasts, endothelial cells and neuroglia. They also induce other cell types to differentiate. For example, they act synergistically with nerve growth factor to stimulate neurite outgrowth from a pheochromocytoma cell line (PC12). We propose that after injury to tissues, including the central nervous system, purine nucleosides and nucleotides interact synergistically with other growth factors. They stimulate proliferation and morphological changes in the various cell types involved in the wound healing response. In the central nervous system this response includes glial proliferation, capillary endothelial cell proliferation, and sprouting of nerve axons. Since many actions of extracellular purines are mediated through specific cell surface receptors, this hypothesis has broad pharmacological implications.