Implication of galectin-3 in Wnt signaling
Implication of galectin-3 in Wnt signaling
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DOI：
10.1158/0008-5472.can-05-0104
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发表时间：
2005-05-01
期刊：
影响因子：
11.2
通讯作者：
Raz, A
中科院分区：
文献类型：
--
作者：
Shimura, T;Takenaka, Y;Raz, A
半乳糖凝集素-3（Galectin-3，gal-3）是β-半乳糖苷结合蛋白家族的一员，是连环蛋白的结合伴侣。对人gal-3序列的分析揭示了与β-连环蛋白的结构相似性，因为它也包含糖原合成酶激酶-3 β（GSK-3 β）磷酸化的共有序列（S92 XXXS 96），并且可以作为其底物。此外，Axin是Wnt的一种调节蛋白，与β-连环蛋白形成复合物，也使用与此处通过缺失突变体分析鉴定的相同序列基序结合半乳糖醛酸-3。本文提供的数据证实了gal-3是Wnt/β-连环蛋白信号通路中的关键调节因子，并突出了gal-3和β-连环蛋白之间的功能相似性。
Galectin-3 (gal-3), a member of the beta-galactoside-binding proteins family, was identified as a binding partner of catenin. Analysis of the human gal-3 sequence reveled a structural similarity to beta-catenin as it also contains the consensus sequence (S92XXXS96) for glycogen synthase kinase-3 beta (GSK-3 beta) phosphorylation and can serve as its substrate. In addition, Axin, a regulator protein of Wnt that complexes with beta-catenin, also binds gal-3 using the same sequence motif identified here by a deletion mutant analysis. The data presented here give credence to the suggestion that gal-3 is a key regulator in the Wnt/ beta-catenin signaling pathway and highlight the functional similarities between gal-3 and beta-catenin.