Duration of vitrectomy and postoperative cataract in the vitrectomy for macular hole study
Duration of vitrectomy and postoperative cataract in the vitrectomy for macular hole study
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DOI：
10.1016/s0002-9394(01)01263-6
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发表时间：
2001-12-01
影响因子：
4.2
通讯作者：
Freeman, WR
中科院分区：
文献类型：
--
作者：
Cheng, LY;Azen, SP;Freeman, WR
- 目得：在玻璃体切除术治疗黄斑裂孔研究中，报告玻璃体切除术的持续时间以及其他风险因素与核硬化和后囊下白内障进展之间的相关性。设计：随机对照临床试验中嵌套的队列研究。方法：使用类似于透镜混浊分类系统II的系统，在基线和术后6、12和24个月对74例患者的玻璃体切除术和对侧眼的核硬化（NS）和后囊下白内障（PSC）进行评分。年龄、基线血压和屈光力以及手术持续时间被评估为NS或PSC进展和白内障摘除的风险因素。研究结果：玻璃体切除术眼手术组的NS进展发生率在6个月时为81%，1年时为98%，2年随访时为100%。相比之下，对照组对侧眼的NS进展在6个月时仅为18%，1年时为20%，2年时为8%。在整个随访期间，手术组PSC进展的发生率保持在约11%，并不显著高于对照组的3%至5%的发生率。玻璃体切除术与NS白内障的进展（P <0.001）和白内障摘除术（P <0.01）显著相关。手术时间小于中位值（60分钟）的患眼之间的NS评分、PSC评分或进展率无统计学显著差异。或超过中位手术持续时间。此外，将手术持续时间≤ 45分钟的患眼与手术持续时间超过75分钟的患眼进行比较时，未发现显著差异。年龄、血压和屈光力不是NS和PSC进展的预测因素。结论：虽然玻璃体切除术是NS进展的一个危险因素，但玻璃体切除术的持续时间并不增加风险。(C)2001年，Elsevier Science Inc. All rights reserved.
- PURPOSE: To report the association between duration of vitrectomy, as well as other risk factors, and the progression of nuclear sclerosis and posterior subcapsular cataract in the Vitrectomy for Macular Hole Study.- DESIGN: A cohort study nested within a randomized controlled clinical trial.- METHODS: Using a system similar to the Lens Opacities Classification System II, nuclear sclerosis (NS) and posterior subcapsular cataract (PSC) were scored in the vitrectomy and fellow eye of 74 patients at baseline and at 6, 12, and 24 months postoperatively. Age, baseline blood pressure and refractive power, and duration of surgery were evaluated as risk factors for NS or PSC progression and cataract extraction.- RESULTS: The incidence of NS progression in the surgical group of vitrectomy eyes was 81% at 6 months, 98% at 1 year, and 100% at 2 years of follow-up. In contrast, NS progression in the control group of fellow eyes was only 18% at 6 months, 20% at 1 year, and 8% at 2 years. The incidence of PSC progression in the surgical group remained at approximately 11% throughout follow,up, which was not significantly higher than the 3% to 5% incidence in the control group. Vitrectomy was significantly related to progression of NS cataract (P < .001) and cataract extraction (P < .01). No statistically significant differences were found for NS scores, PSC scores, or progression rates between eyes that had less than median surgical duration (60 min.) or more than the median surgical duration. Additionally, no significant differences were found when eyes that experienced 45 minutes or less surgical duration were compared with eyes that endured more than 75 minutes surgical duration. Age, blood pressure, and refractive power were not found to be predictors for NS and PSC progression.- CONCLUSIONS: Although vitrectomy is a risk factor for NS progression, the duration of vitrectomy does not increase the risk. (C) 2001 by Elsevier Science Inc. All rights reserved.