QUANTIFICATION OF CUTANEOUS SENSORY NERVES AND THEIR SUBSTANCE-P CONTENT IN PSORIASIS
QUANTIFICATION OF CUTANEOUS SENSORY NERVES AND THEIR SUBSTANCE-P CONTENT IN PSORIASIS
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DOI：
10.1111/1523-1747.ep13071340
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发表时间：
1989-01-01
影响因子：
6.5
通讯作者：
FARBER, EM
中科院分区：
文献类型：
--
作者：
NAUKKARINEN, A;NICKOLOFF, BJ;FARBER, EM
本研究的目的是扩展我们以前的假设，即银屑病的炎症反应是神经源性的，P物质介导的炎症。为此目的，neurobient-positive感觉神经纤维的图案进行了研究，这些纤维的长度和P物质含量的测量形态学在真皮和表皮的银屑病皮损，银屑病，但无病变的皮肤，和对照皮肤的隔间。银屑病皮损的表皮和真皮中神经递质阳性纤维的分布明显比无皮损银屑病或对照皮肤密集。虽然P物质已知在组织中迅速降解，并且其在切片中的实际浓度未知，但在银屑病病变中含有P物质的神经增加，这种增加在表皮神经纤维中是显著的。无皮损银屑病和对照皮肤之间的测量参数没有显着差异。这些结果表明，银屑病斑块中感觉神经的模式发生了改变，P物质可能是炎症过程中的重要介质，有助于银屑病病变的启动或维持。
The aim of the present study was to extend our previous hypothesis that the inflammatory reaction in psoriasis is neurogenic, and that substance P mediates the inflammation. For this purpose, the pattern of neurofilament-positive sensory nerve fibers was studied and the lengths and substance P content of these fibers measured morphometrically in dermal and epidermal compartments of the psoriatic lesions, psoriatic but lesion-free skin, and control skin. The epidermis and dermis of the psoriatic lesions were significantly more densely innervated with neurofilament-positive fibers than either lesion-free psoriatic or control skin. Although substance P is known to be rapidly degraded in tissues, and its actual concentrations in the sections were unknown, there was an increase in sustance P containing nerves in the psoriatic lesion, the increase being significant in the epidermal nerve fibers. No significant differences in the measured parameters were obtained between lesion-free psoriatic and control skin. These results indicate that there is an altered pattern of sensory nerves in a psoriatic plaque and that substance P may be an important mediator in the inflammatory processes that contribute either to the initiation or maintenance of a psoriatic lesion.