Interleukin-6 increases sensitivity to the locomotor-stimulating effects of amphetamine in rats
Interleukin-6 increases sensitivity to the locomotor-stimulating effects of amphetamine in rats
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DOI：
10.1016/s0006-8993(99)02063-6
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发表时间：
1999-11-20
期刊：
影响因子：
2.9
通讯作者：
Wise, RA
中科院分区：
文献类型：
--
作者：
Zalcman, S;Savina, I;Wise, RA
白细胞介素（IL）-6介导脑免疫相互作用，影响出生后中脑和基底前脑细胞的存活，影响中脑皮质边缘多巴胺和5-羟色胺神经传递，并且与各种中枢神经系统疾病有关。在本研究中，单次注射IL-6（1或2 μ g/Long-Evans大鼠，i. p.）引起了自发活动的适度升高。然而，重复间歇注射IL-6（每天注射5次; 1 μ g/大鼠）并没有增加自发活动。尽管如此，重复IL-6治疗增加的敏感性运动刺激作用的1.0和0.5毫克/公斤安非他明，当测试5，7，或14天后中断的细胞因子治疗。急性IL-6注射改变自发活动的能力和重复IL-6注射产生持久的致敏作用的自发刺激安非他明的能力表明，这种细胞因子与中脑边缘多巴胺系统，一个系统涉及精神分裂症，成瘾和运动障碍的方面的相互作用。IL-6引起对安非他明反应性的持久变化的事实意味着免疫原性刺激可以改变脑回路的机制，改变其对看似无关的后续刺激或事件的敏感性。(C)1999 Elsevier Science B. V.保留所有权利。
Interleukin (IL)-6 mediates brain-immune interactions, influences the survival of postnatal mesencephalic and basal forebrain cells, influences mesocorticolimbic dopamine and serotonin neurotransmission, and is linked with various central nervous system disorders. In the present study, single injections of IL-6 (1 or 2 mu g/Long-Evans rat, i.p.) induced modest elevations of locomotor activity. The locomotor increases were not augmented by repeated intermittent injections of IL-6 (five daily injections; 1 mu g/rat), however. Nonetheless, repeated IL-6 treatment increased sensitivity to the locomotor-stimulating effects of 1.0 and 0.5 mg/kg amphetamine, when tested 5, 7, or 14 days following interruption of the cytokine treatment. The ability of acute IL-6 injections to alter locomotor activity and the ability of repeated IL-6 injections to produce long-lasting sensitization to the locomotor-stimulating effects of amphetamine suggest an interaction of this cytokine with the mesolimbic dopamine system, a system implicated in aspects of schizophrenia, addiction, and movement disorders. The fact that IL-6 caused a lasting change in responsiveness to amphetamine implies a mechanism by which immunogenic stimuli can alter brain circuitry, changing its sensitivity to seemingly unrelated subsequent stimuli or events. (C) 1999 Elsevier Science B.V. All rights reserved.