Low-cholesterol diet: enhancement of effect of CDCA in patients with gall stones.
Low-cholesterol diet: enhancement of effect of CDCA in patients with gall stones.
复制标题
低胆固醇饮食：增强CDCA对胆结石患者的作用。
作者：
D. Maudgal;R. Bird;W. Blackwood;T. Northfield
15例胆结石患者睡前口服鹅去氧胆酸(CDCA)15 mg/kg，观察改变类固醇摄入量对空腹胆汁胆固醇饱和指数(SI)的影响。在实验I中，15名不限制饮食的患者的SI为0.87+/-0.04(平均值+/-SE)，在住院一周后降至0.75+/-0.04，每天摄入100 mg胆固醇。在实验II中，7名患者作为门诊患者被给予四种不同的饮食方案，每种方案随机持续一个月。每天摄入600毫克胆固醇的患者的SI平均值为0.72+/-0.05，而服用100毫克胆固醇的患者的SI降至0.67+/-0.05。在两种饲料中添加植物甾醇(每天3g)后，平均SIS分别提高到0.80+/-0.05和0.77+/-0.05。胆汁中CDCA的百分比不受胆固醇和植物类固醇摄入量变化的影响。我们的结论是，低胆固醇饮食，但不是大量摄入植物类固醇，可以增强CDCA对胆结石患者的疗效。
Fifteen patients with gall stones who were taking chenodeoxycholic acid(CDCA) 15 mg/kg at bedtime participated in two separate experiments to investigate the effects of altering sterol intake on the cholesterol saturation index (SI) of fasting gall-bladder bile. In experiment I the 15 patients on an unrestricted diet had a SI of 0.87 +/- 0.04 (mean +/- SE of mean), which fell to 0.75 +/- 0.04 after one week in hospital on a diet of 100 mg cholesterol daily. In experiment II seven of the patients were given four different dietary regimens lasting one month each in random order as outpatients. On a diet of 600 mg of cholesterol daily the mean SI was 0.72 +/- 0.05, which fell to 0.67 +/- 0.05 when the patients were put on a 100 mg cholesterol diet. The addition of plant sterols (3 g daily) to both diets raised the mean SIs to 0.80 +/- 0.05 and 0.77 +/- 0.05 respectively. The percentage CDCA in bile was unaffected by alterations in the cholesterol and plant sterol intakes. We conclude that a low-cholesterol diet but not a high intake of plant sterols enhances the effect of CDCA in patients with gall stones.