Super high flux hemofiltration: a new technique for cytokine removal
Super high flux hemofiltration: a new technique for cytokine removal
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DOI：
10.1007/s00134-002-1261-2
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发表时间：
2002-05-01
影响因子：
38.9
通讯作者：
Tipping, P
中科院分区：
文献类型：
--
作者：
Uchino, S;Bellomo, R;Tipping, P
目的：测试使用大孔径滤血器（超高通量血液滤过）进行血液滤过是否能有效去除细胞因子。设计：离体研究。地点：三级医院重症监护室实验室。患者和参与者：五名健康志愿者。干预措施：向血液中加入 1 mg 内毒素，然后通过带有大孔聚酰胺超高通量血液过滤器（标称截止点：100 kDa）的封闭血液过滤回路进行循环。以1升/小时或6升/小时的超滤液流量进行血液过滤。从动脉、静脉和超滤取样口取样。测量和结果：在1l/h下，白介素(IL)-1β、IL-6和IL-10的筛分系数(SC)达到0.6以上，IL-8和TNF-α的SC达到0.3以上。当超滤速率从 I l/h 增加到 6 l/h 时，所有细胞因子（IL-1 除外）的 SC 均减少（p
Objective: To test whether hemofiltration using a hemofilter with large pores (super high flux hemofiltration) achieves effective cytokine removal. Design: Ex vivo study. Setting: Laboratory of an intensive care unit in a tertiary hospital. Patients and participants: Five healthy volunteers. Interventions: Blood was spiked with I mg of endotoxin and then circulated through a closed hemofiltration circuit with a large pore polyamide super high flux hemofilter (nominal cut-off point: 100 kDa). Hemofiltration was conducted at I l/h or 6 l/h of ultrafiltrate flow. Samples were taken from the arterial, venous and ultrafiltration sampling ports. Measurements and results: Sieving coefficients (SC) above 0.6 were achieved for interleukin (IL)-1beta, IL-6 and IL-10 and SCs above 0.3 were achieved for IL-8 and TNF-alpha at I l/h. SCs of all cytokines (except IL-1) were reduced when the ultrafiltration rate was increased from I l/h to 6 l/h (p