The RAS genes: a homeostatic device in Saccharomyces cerevisiae longevity☆
The RAS genes: a homeostatic device in Saccharomyces cerevisiae longevity☆
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RAS基因：酿酒酵母长寿的稳态装置☆
DOI：
10.1016/s0197-4580(99)00095-0
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发表时间：
1999
影响因子：
4.2
通讯作者：
S. Jazwinski
中科院分区：
文献类型：
--
作者：
S. Jazwinski
对酵母复制寿命的遗传分析揭示了代谢控制和抗逆性的重要性。它还阐明了RAS基因在决定长寿中的关键作用，它通过维持体内平衡来发挥作用。这一角色似乎是通过协调各种细胞过程来完成的。代谢控制似乎在包括抗逆性在内的这些细胞过程中占据着中心位置。酵母中代谢控制的一些特征类似于秀丽线虫成虫寿命的daf途径的影响，以及选择延长黑腹果蝇寿命的代谢结果，以及哺乳动物热量限制的一些特征。分裂和不分裂细胞之间的区别被认为对衰老过程没有人们普遍认为的那么重要，因为这些细胞类型是代谢连续体的一部分，在代谢连续体中，总代谢能力决定寿命。因此，对酵母老化的研究可能有助于理解大脑老化的过程。
The genetic analysis of the yeast replicative life span has revealed the importance of metabolic control and resistance to stress. It has also illuminated the pivotal role in determining longevity that the RAS genes play by the maintenance of homeostasis. This role appears to be performed by the coordination of a variety of cellular processes. Metabolic control seems to occupy a central position among these cellular processes that include stress resistance. Some of the features of metabolic control in yeast resemble the effects of the daf pathway for adult longevity in Caenorhabditis elegans and the metabolic consequences of selection for extended longevity in Drosophila melanogaster, as well as some of the features of caloric restriction in mammals. The distinction between dividing and nondividing cells is proposed to be less important for the aging process than generally believed because these cell types are part of a metabolic continuum in which the total metabolic capacity determines life span. As a consequence, the study of yeast aging may be helpful in understanding processes occurring in the aging brain.