Corrigendum to "Wnt5a Signaling in Normal and Cancer Stem Cells".
Corrigendum to "Wnt5a Signaling in Normal and Cancer Stem Cells".
复制标题
正常和癌症干细胞中的 Wnt5a 信号传导（2017 年卷、5295286、2017 年）
DOI：
10.1155/2017/3467360
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发表时间：
2017
影响因子：
4.3
通讯作者：
Zhang S
中科院分区：
文献类型：
--
作者：
Zhou Y;Kipps TJ;Zhang S
Wnt5a参与激活几种非典型Wnt信号通路，这些非典型Wnt信号通路可以以受体环境依赖的方式抑制或激活典型Wnt/β - catenin信号通路。Wnt5a信号对于调节正常的发育过程至关重要，包括干细胞的自我更新、增殖、分化、迁移、粘附和极性。此外，Wnt5a信号的异常激活或抑制正在成为癌症进展中的一个重要事件，同时发挥致癌和抑瘤作用。最近的研究表明，Wnt5a信号通路参与调节正常和癌症干细胞的自我更新、癌细胞增殖、迁移和侵袭。在这篇文章中，我们回顾了Wnt5a信号在干细胞胚胎发生和正常或肿瘤乳腺或卵巢中的分子机制和作用的最新发现，强调Wnt5a可能根据靶细胞表达的表面受体而对靶细胞产生不同的影响。
Wnt5a is involved in activating several noncanonical Wnt signaling pathways, which can inhibit or activate canonical Wnt/β‐catenin signaling pathway in a receptor context‐dependent manner. Wnt5a signaling is critical for regulating normal developmental processes, including stem cell self‐renewal, proliferation, differentiation, migration, adhesion, and polarity. Moreover, the aberrant activation or inhibition of Wnt5a signaling is emerging as an important event in cancer progression, exerting both oncogenic and tumor suppressive effects. Recent studies show the involvement of Wnt5a signaling in regulating normal and cancer stem cell self‐renewal, cancer cell proliferation, migration, and invasion. In this article, we review recent findings regarding the molecular mechanisms and roles of Wnt5a signaling in stem cells in embryogenesis and in the normal or neoplastic breast or ovary, highlighting that Wnt5a may have different effects on target cells depending on the surface receptors expressed by the target cell.