Nicotine content of electronic cigarettes, its release in vapour and its consistency across batches: regulatory implications
Nicotine content of electronic cigarettes, its release in vapour and its consistency across batches: regulatory implications
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DOI：
10.1111/add.12410
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发表时间：
2014-03-01
期刊：
影响因子：
6
通讯作者：
McRobbie, Hayden
中科院分区：
文献类型：
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作者：
Goniewicz, Maciej L.;Hajek, Peter;McRobbie, Hayden
电子烟（EC）作为吸烟的更安全替代品可能具有潜在的公共健康益处，但人们对EC是否应被许可作为药物并准确标记尼古丁含量提出了疑问。这项研究确定了英国最受欢迎的EC品牌烟弹的尼古丁含量以及它们在蒸汽中释放的尼古丁水平，并估计了同一产品不同批次尼古丁输送的安全性和一致性，作为单个品牌和行业内质量控制的代表。（六种产品）具有高的互联网知名度。测量每个品牌的两个样品间隔4周购买，结果同一批烟弹的尼古丁含量差异达12%，同一品牌不同批次之间的相对标准偏差（RSD）和平均差异范围为1% [95%置信区间（CI）=-5至7%]至20%（95% CI=14-25%），5个品牌为31%（95% CI=21-39%）。本研究中使用的抽吸时间表蒸发了笔芯中10-81%的尼古丁。300喷次的尼古丁释放量范围为约2 mg ~约15 mg，与烟油中尼古丁含量的变化无显著相关性（r=0.06，P=0.92）。没有测试的产品允许访问电子液体或产生的蒸汽尼古丁浓度高达传统cigaretts.ConclusionsThere是尼古丁毒性的主要电子香烟（EC）品牌在英国的风险很小。来自给定品牌的蒸汽中尼古丁浓度的变化很小。电子烟液中的尼古丁浓度与蒸汽中的尼古丁没有很好的相关性。其他欧洲共同体品牌的品质可能较低，需要实施消费者保护法规，但就尼古丁含量标签的准确性和尼古丁过量的风险而言，似乎没有必要在这些保障措施之上进行监管。
Background and aimsElectronic cigarettes (EC) may have a potential for public health benefit as a safer alternative to smoking, but questions have been raised about whether EC should be licensed as a medicine, with accurate labelling of nicotine content. This study determined the nicotine content of the cartridges of the most popular EC brands in the United Kingdom and the nicotine levels they deliver in the vapour, and estimated the safety and consistency of nicotine delivery across batches of the same product as a proxy for quality control for individual brands and within the industry.MethodsWe studied five UK brands (six products) with high internet popularity.MeasurementsTwo samples of each brand were purchased 4 weeks apart, and analysed for nicotine content in the cartridges and nicotine delivery in vapour.ResultsThe nicotine content of cartridges within the same batch varied by up to 12% relative standard deviation (RSD) and the mean difference between different batches of the same brand ranged from 1% [95% confidence interval (CI)=-5 to 7%] to 20% (95% CI=14-25%) for five brands and 31% (95% CI=21-39%) for the sixth. The puffing schedule used in this study vaporized 10-81% of the nicotine present in the cartridges. The nicotine delivery from 300 puffs ranged from approximate to 2mg to approximate to 15mg and was not related significantly to the variation of nicotine content in e-liquid (r=0.06, P=0.92). None of the tested products allowed access to e-liquid or produced vapour nicotine concentrations as high as conventional cigarettes.ConclusionsThere is very little risk of nicotine toxicity from major electronic cigarette (EC) brands in the United Kingdom. Variation in nicotine concentration in the vapour from a given brand is low. Nicotine concentration in e-liquid is not well related to nicotine in vapour. Other EC brands may be of lower quality and consumer protection regulation needs to be implemented, but in terms of accuracy of labelling of nicotine content and risks of nicotine overdose, regulation over and above such safeguards seems unnecessary.