Frequency and Distribution of Lymph Node Metastases in Epithelial Ovarian Cancer Significance of Serous Histology
Frequency and Distribution of Lymph Node Metastases in Epithelial Ovarian Cancer Significance of Serous Histology
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DOI：
10.1097/igc.0b013e31820575db
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发表时间：
2011-02-01
影响因子：
4.8
通讯作者：
Perovic, Danko
中科院分区：
文献类型：
--
作者：
Haller, Herman;Mamula, Ozren;Perovic, Danko
背景资料：本回顾性研究的目的是评估的发病率和分布的淋巴结转移的浆液性与非浆液性组织学亚型上皮性卵巢cancer.Methods：患者主要治疗前期手术，包括盆腔和腹主动脉旁系统淋巴结清扫术，到左肾静脉的水平，在任何一种化疗管理。患者根据肿瘤组织学分为2组：浆液性（包括混合组织学与浆液成分的情况下）和non-serous group.Results：共173例患者符合纳入标准，76和97例患者分别为浆液性和非浆液性卵巢癌。在浆液性和非浆液性组织学组中，分别在59.3%（45/76）和14.4%（14/97）的患者中发现阳性淋巴结。两组间3个区域（盆腔和主动脉旁区域，肠系膜下动脉下方和上方）的阳性淋巴结分布无差异。早期传播，包括1或2个阳性淋巴结主要是发现在两组，浆液性和非浆液性的主动脉旁区域，而3个或更多的淋巴结的患者中的阳性淋巴结的分布显示平等存在于盆腔和主动脉旁regions.Conclusions：浆液性卵巢癌是更容易转移到淋巴结比非浆液性组织学类型。然而，这两组之间的淋巴结分布模式没有差异，并且在盆腔和主动脉旁区域相似。
Background: The aim of this retrospective study was to evaluate the incidence and distribution of nodal metastases in relation to the serous versus nonserous histological subtypes of epithelial ovarian cancer.Methods: Patients were treated primarily with upfront surgery, including pelvic and para-aortic systematic lymphadenectomy, up to the level of the left renal vein, before any kind of chemotherapy administration. Patients were classified according the tumor histology into 2 groups: serous (including the cases of mixed histology with a serous component) and nonserous group.Results: A total of 173 patients fulfilled the inclusion criteria; 76 and 97 patients had serous and nonserous ovarian carcinoma, respectively. Positive lymph nodes were found in 59.3% (45/76) and 14.4% (14/97) of patients in the serous and nonserous histology groups, respectively. There was no difference in positive node distribution in 3 regions (pelvic and para-aortic regions, below and above the inferior mesenteric artery) between these 2 groups. Early spread including 1 or 2 positive lymph nodes was predominantly found in the para-aortic region in both groups, serous and nonserous, whereas distribution of positive nodes in patients with 3 or more lymph nodes shows equal presence in pelvic and para-aortic regions.Conclusions: Serous ovarian carcinomas are much more prone to metastasize to lymph nodes than nonserous histological types. However, the pattern of lymph node distribution did not differ between these 2 groups and was similar in the pelvic and para-aortic regions.