Nonneutralizing antibodies are able to inhibit human immunodeficiency virus type 1 replication in macrophages and immature dendritic cells
Nonneutralizing antibodies are able to inhibit human immunodeficiency virus type 1 replication in macrophages and immature dendritic cells
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DOI：
10.1128/jvi.02625-05
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发表时间：
2006-06-01
影响因子：
5.4
通讯作者：
Moog, Christiane
中科院分区：
文献类型：
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作者：
Holl, Vincent;Peressin, Maryse;Moog, Christiane
到目前为止，只有5株能中和多种初级分离株的单抗已被鉴定出来。我们发现，以植物血凝素刺激的外周血单核细胞为靶点，一些传统的中和试验没有中和活性的单抗，能有效地抑制人类免疫缺陷病毒1型(HIV-1)PI在巨噬细胞和未成熟树突状细胞(IDC)中的复制。其抑制机制不同于通过Fab片段发生的中和感染性，涉及F部分与巨噬细胞和IDC上存在的Fc-Gamma Rs的相互作用。我们建议，如果这种非中和抑制性抗体限制了艾滋病毒的粘膜传播，它们应该通过疫苗接种来诱导。
Only five monoclonal antibodies (MAbs) neutralizing a broad range of primary isolates (PI) have been identified up to now. We have found that some MAbs with no neutralizing activities according to the "conventional" neutralization assay, involving phytohemagglutinin-stimulated peripheral blood mononuclear cells as targets, efficiently inhibit the replication of human immunodeficiency virus type 1 (HIV-1) PI in macrophages and immature dendritic cells (iDC). The mechanism of inhibition is distinct from the neutralization of infectivity occurring via Fab fragments and involves the interaction of the F portion with the Fc gamma Rs present on macrophages and iDC. We propose that, if such nonneutralizing inhibitory antibodies limit mucosal HIV transmission, they should be induced by vaccination.