Mental stress induces sustained elevation of blood pressure and lipid peroxidation in postmenopausal women
Mental stress induces sustained elevation of blood pressure and lipid peroxidation in postmenopausal women
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DOI：
10.1016/j.lfs.2007.10.018
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发表时间：
2008-01-02
期刊：
影响因子：
6.1
通讯作者：
Yoshida, Ken-ichi
中科院分区：
文献类型：
--
作者：
Morimoto, Keiko;Morikawa, Mayuko;Yoshida, Ken-ichi
精神压力被认为是心血管事件的基础，但有信息表明精神压力引起的氧化应激与女性心血管反应有关。使用血浆 4-羟基-2-壬烯醛 (HNE) 的灵敏检测作为氧化应激的标志物，我们研究了绝经前和绝经后女性的升压反应与精神或身体应激引起的氧化应激之间的关系。健康受试者（7 名绝经后和 8 名绝经前女性，卵泡早期和晚期）分别承受由色词测试 (CWT) 和等距握力引起的精神和身体压力。 CWT 导致舒张压 (DBP) 快速升高，绝经后女性的舒张压水平高于绝经前女性 (p
Mental stress is thought to underlie cardiovascular events, but there is information on oxidative stress induced by mental stress in association with cardiovascular responses in women. Using a sensitive assay for plasma 4-hydroxy-2-nonenal (HNE), as a marker for oxidative stress, we addressed the relation between pressor responses and oxidative stress induced by mental or physical stress in premenopausal and postmenopausal women. Healthy subjects (7 postmenopausal and 8 premenopausal women, in early and late follicular phases) were subjected to mental and physical stress evoked by a Color Word Test (CWT) and isometric handgrip, respectively. The CWT induced a rapid elevation of diastolic blood pressure (DBP), at a higher level in the postmenopausal than in the premenopausal women (p