AQUAGENIC URTICARIA. CONTACT SENSITIVITY REACTION TO WATER.
AQUAGENIC URTICARIA. CONTACT SENSITIVITY REACTION TO WATER.
复制标题
水生荨麻疹。
DOI：
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发表时间：
1964
期刊：
影响因子：
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通讯作者：
H. Rawnsley
中科院分区：
文献类型：
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作者：
W. Shelley;H. Rawnsley
多年来，由于高温、情绪或劳累，人们注意到某些人会出现一种独特的、强烈瘙痒的麻疹。大量的小斑块被贴上了“胆碱能性荨麻疹”的标签。皮肤表面敏感区域的临界湿化会引发胆碱能性荨麻疹，可以通过在水浴中浸泡几分钟、接触蒸馏水或自身出汗来实现。水与皮脂或皮脂腺的一种成分反应，产生组胺释放剂，它被吸收，随后组胺从小叶周围肥大细胞中排出。这会产生瘙痒、轴突反射性红斑和滤泡性荨麻疹。皮肤的惰性油膜和全身性抗组胺药物已被发现在预防发作方面有效。
For years a distinctive and intensely pruritic form of hives has been noted in certain people as a result of heat, emotion, or exertion. The numerous small lesions have been labeled "cholinergic urticaria." Critical wetting of the sensitive areas of the skin surface, which triggers cholinergic urticaria, can be achieved by a few minutes immersion in a water bath, contact with distilled water, or sweating itself. Water reacts with a component of the sebum or sebaceous gland to produce a histamine liberator which is absorbed with subsequent discharge of histamine from the perifollicular mast cells. This produces pruritus, axon-reflex erythema, and follicular urticaria. Inert oil coating of the skin and systemic antihistaminics have been found effective in preventing attacks.