Teleost model for studying the effects of chemicals on female reproductive endocrine function.
Teleost model for studying the effects of chemicals on female reproductive endocrine function.
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用于研究化学物质对女性生殖内分泌功能影响的硬骨鱼模型。
DOI：
10.1002/jez.1402560421
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Thomas,P
中科院分区：
文献类型：
--
作者：
Thomas,P
本文研究了几种哺乳动物生殖毒素对雌性大西洋小黄鱼生殖内分泌功能的影响。在卵巢复发期间，将黄鱼暴露于亚致死浓度的铅、镉、苯并[a]芘（BaP）或多氯联苯混合物（Aroclor 1254）1个月。在暴露于所有四种化学物质后，生殖发生了改变。镉暴露后血浆生殖激素水平和分泌速率增加，导致卵巢早熟。相反，铅、苯并（a）芘或多氯联苯1254治疗引起循环类固醇激素水平和卵巢生长下降。暴露于几种生殖毒素后，还观察到离体垂体和卵巢组织在体外孵育时激素分泌速率的变化。因此，大西洋黄花鱼是研究生殖毒素对雌性生殖内分泌功能影响的敏感模型。我们的研究结果表明，这些化学物质可能作用于下丘脑-垂体-性腺轴的各个部位，以改变生殖内分泌功能。
The effects of several mammalian reproductive toxins on reproductive endocrine function in female Atlantic croaker (Micropogonias undulatus) were examined. Croaker were exposed to sublethal concentrations of lead, cadmium, benzo[a]pyrene (BaP), or a polychlorinated biphenyl mixture (Aroclor 1254) for 1 month during the period of ovarian recrudescence. Reproduction was altered after exposure to all four chemicals. The plasma levels and secretion rates of reproductive hormones were augmented after exposure to cadmium resulting in precocious ovarian growth. In contrast, treatment with lead, BaP, or Aroclor 1254 caused a decline in circulating steroid hormone levels and ovarian growth. Changes in hormone secretion rates from isolated pituitary and ovarian tissues incubated in vitro were also observed after exposure to several of the reproductive toxins. It is concluded that the Atlantic croaker is a sensitive model for examining the effects of reproductive toxins on female reproductive endocrine function. Our results indicate that these chemicals may act at various sites on the hypothalamus‐pituitary‐gonadal axis to alter reproductive endocrine function.