Design, synthesis, and biological evaluation of a scaffold for iGluR ligands based on the structure of (-)-kaitocephalin.
Design, synthesis, and biological evaluation of a scaffold for iGluR ligands based on the structure of (-)-kaitocephalin.
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DOI：
10.1016/j.bmcl.2008.11.004
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发表时间：
2006-04
影响因子：
2.7
通讯作者：
R. Vaswani;A. Limon;J. M. Reyes-Ruiz;R. Miledi;A. Chamberlin
中科院分区：
文献类型：
--
作者：
R. Vaswani;A. Limon;J. M. Reyes-Ruiz;R. Miledi;A. Chamberlin
设计和合成了四种结构上与已知的离子型谷氨酸受体拮抗剂(−)-凯特脑素相关的吡咯烷支架。此外，还公开了这些化合物的生物评价的初步结果。
The design and synthesis of four pyrrolidine scaffolds that are structurally related to the known ionotropic glutamate receptor antagonist, (−)-kaitocephalin, is described. Additionally, preliminary results of the biological evaluation of these compounds are disclosed.