Spectral Domain Optical Coherence Tomography and Autofluorescence in a Case of Acute Posterior Multifocal Placoid Pigment Epitheliopathy Mimicking Vogt-Koyanagi-Harada Disease: Case Report and Review of Literature
Spectral Domain Optical Coherence Tomography and Autofluorescence in a Case of Acute Posterior Multifocal Placoid Pigment Epitheliopathy Mimicking Vogt-Koyanagi-Harada Disease: Case Report and Review of Literature
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DOI：
10.3109/09273948.2010.521610
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发表时间：
2011-02-01
影响因子：
3.3
通讯作者：
Fawzi, Amani A.
中科院分区：
文献类型：
--
作者：
Lee, Grant E.;Lee, Brandon W.;Fawzi, Amani A.
目的：报道一例伴有渗出性视网膜脱离的急性后多灶性鳞状色素上皮病（APMPPE）病例，模拟急性Vogt-Koyanagi-Harada（VKH）病并回顾相关影像学文献。方法：眼科检查、实验室评估、荧光素血管造影和基线时进行的B扫描超声检查，以及频域光学相干断层扫描（OCT）和眼底自发荧光在初次就诊时以及 5 天、1 个月和 3 个月的随访时进行。结果：OCT 显示急性期外层视网膜高反射和视网膜下液，5 天后消失。 OCT 和超声检查发现脉络膜增厚。视网膜色素上皮病变急性时自发荧光低，但在病程后期变为高自发荧光。 结论：目前，模仿急性 VKH 的 APMPPE 的临床和影像学表现可能有相当大的重叠，因此很难区分这两种疾病。脑脊液分析和后续检查有助于做出正确的诊断。
Purpose: To report a case of acute posterior multifocal placoid pigment epitheliopathy (APMPPE) with exudative retinal detachment, simulating acute Vogt-Koyanagi-Harada (VKH) disease and to review relevant imaging literature.Methods: Ophthalmologic examination, laboratory evaluation, fluorescein angiography, and B-scan ultrasonography performed at baseline, as well as spectral domain optical coherence tomography (OCT) and fundus autofluorescence performed upon initial presentation and at 5-day, 1-month, and 3-month follow-up.Results: OCT demonstrated outer retinal hyperreflectance and subretinal fluid in the acute phase that disappeared 5 days later. Choroidal thickening was noted on OCT and ultrasonography. Retinal pigment epithelium lesions were hypoautofluorescent acutely but became hyperautofluorescent later in the disease course.Conclusions: At presentation, there can be considerable overlap in both clinical and imaging findings in APMPPE mimicking acute VKH, making it difficult to differentiate these two entities. Cerebral spinal fluid analysis and follow-up examinations could help in arriving at proper diagnosis.