Neonatal intrahippocampal immune challenge alters dopamine modulation of prefrontal cortical interneurons in adult rats.
Neonatal intrahippocampal immune challenge alters dopamine modulation of prefrontal cortical interneurons in adult rats.
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DOI：
10.1016/j.biopsych.2009.09.028
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发表时间：
2010-02-15
影响因子：
10.6
通讯作者：
O'Donnell, Patricio
中科院分区：
文献类型：
--
作者：
Feleder, Carlos;Tseng, Kuei Yuan;Calhoon, Gwendolyn G.;O'Donnell, Patricio
在精神分裂症的各种动物模型中，新生儿腹侧海马病变（NVHL）是应用最广泛的模型之一。然而，它的结构效度可能受到质疑，因为没有证据表明精神分裂症中存在病变。其他试图捕捉环境对发育影响的方法包括不同的母体感染模型。由于啮齿类动物出生后早期相当于人类妊娠晚期的大脑发育，我们决定测试是否与注射细菌内毒素脂多糖（LPS）到腹侧海马的新生儿免疫挑战引起的缺陷类似于NVHL报告的interneuron功能。新生儿LPS注射引起了持续升高的细胞因子在几个脑区，赤字的前脉冲抑制声惊吓反应和损失的前额叶皮质快速尖峰的中间神经元多巴胺的反应中的青春期成熟。由NVHL引起的相同的表型可以获得海马内的免疫挑战，这表明围产期环境因素可以影响成年前额叶中间神经元在青春期的成熟。
Among the diverse animal models proposed for schizophrenia, the neonatal ventral hippocampal lesion (NVHL) is one of the most widely used. However, its construct validity can be questioned because there is no evidence of a lesion present in schizophrenia. Other approaches that have tried to capture environmental influences on development include diverse models of maternal infection. As the early postnatal days in rodents are equivalent to the third trimester of human pregnancy in terms of brain development, we decided to test whether a neonatal immune challenge with an injection of the bacterial endotoxin lipopolysaccharide (LPS) into the ventral hippocampus caused deficits in interneuron function similar to those reported for the NVHL. Neonatal LPS injection caused a persistent elevation in cytokines in several brain regions, deficits in prepulse inhibition of the acoustic startle response and a loss of the periadolescent maturation in the response of prefrontal cortical fast-spiking interneurons to dopamine. The same phenotypes elicited by a NVHL can be obtained with an intra-hippocampal immune challenge, suggesting that perinatal environmental factors can affect adult prefrontal interneuron maturation during adolescence.
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影响因子：
1.7
作者：
Pearce, BD;Valadi, NM;Miller, AH
通讯作者：
Miller, AH
影响因子：
17.7
作者：
Maldonado-Aviles, Jaime G.;Curley, Allison A.;Lewis, David A.
通讯作者：
Lewis, David A.
影响因子：
10.6
作者：
Ozawa, K;Hashimoto, K;Iyo, M
通讯作者：
Iyo, M
影响因子：
7.6
作者：
LIPSKA, BK;JASKIW, GE;WEINBERGER, DR
通讯作者：
WEINBERGER, DR
DOI：
10.1523/jneurosci.4166-08.2008
发表时间：
2008-11-26
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Tseng KY;Lewis BL;Hashimoto T;Sesack SR;Kloc M;Lewis DA;O'Donnell P
通讯作者：
O'Donnell P