Correlates of Combination Antiretroviral Adherence Among Recently Diagnosed Older HIV-Infected Adults Between 50 and 64 years.
Correlates of Combination Antiretroviral Adherence Among Recently Diagnosed Older HIV-Infected Adults Between 50 and 64 years.
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DOI：
10.1007/s10461-016-1325-x
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发表时间：
2016-11
影响因子：
4.4
通讯作者：
Rust G
中科院分区：
文献类型：
--
作者：
Abara WE;Adekeye OA;Xu J;Heiman HJ;Rust G
最佳坚持联合抗逆转录病毒治疗对于老年人艾滋病毒感染者 (PLWH) 的健康至关重要，然而，关于坚持和衰老的文献有限。使用来自 29 个州 (N = 5177) 的医疗补助数据，我们探索了老年 PLWH 最佳依从性的相关性。本研究中最佳依从性的发生率较低（32%）。男性比女性更依从（APR = 1.11，95% CI 1.02–1.21，P = 0.0127）；患有三种或多种合并症（APR = 0.67，95 % CI 0.60–0.74，P < 0.001）、两种合并症（APR = 0.86，95 % CI 0.75–0.98，P = 0.0319）和一种合并症（APR = 0.82，95 % CI）的人0.73–0.92，P = 0.0008）比没有任何合并症的人依从性较差；农村地区（APR = 0.90，95% CI 0.63–0.98，P = 0.0385）和小都市地区（APR = 0.82，95% CI 0.72–0.94，P = 0.0032）居民的依从性低于大城市地区居民。最佳依从性不存在种族差异。提供依从性支持、病例管理和同伴导航服务的有针对性的干预措施可能有助于在该人群中实现最佳依从性。
Optimal adherence to combination antiretroviral therapy is essential to the health of older people living with HIV (PLWH), however, the literature on adherence and aging is limited. Using Medicaid data from 29 states (N = 5177), we explored correlates of optimal adherence among older PLWH. The prevalence of optimal adherence was low (32 %) in this study. Males were more adherent than females (APR = 1.11, 95 % CI 1.02–1.21, P = 0.0127); persons with three or more co-morbidities (APR = 0.67, 95 % CI 0.60–0.74, P < 0.001), two co-morbidities (APR = 0.86, 95 % CI 0.75–0.98, P = 0.0319) and one co-morbidity (APR = 0.82, 95 % CI 0.73–0.92, P = 0.0008) were less adherent than those without any co-morbidity; and residents of rural areas (APR = 0.90, 95 % CI 0.63–0.98, P = 0.0385) and small metropolitan areas (APR = 0.82, 95 % CI 0.72–0.94, P = 0.0032) were less adherent than residents of large metropolitan areas. There were no racial differences in optimal adherence. Targeted interventions that provide adherence support, case management, and peer navigation services may be of benefit in achieving optimal adherence in this population.