Perforating neutrophilic and granulomatous dermatitis of the newborn -: A clue to immunodeficiency
Perforating neutrophilic and granulomatous dermatitis of the newborn -: A clue to immunodeficiency
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DOI：
10.1111/j.1525-1470.2007.00388.x
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发表时间：
2007-05-01
影响因子：
1.5
通讯作者：
Zambrano, Antonio
中科院分区：
文献类型：
--
作者：
Torrelo, Antonio;Vera, Angel;Zambrano, Antonio
我们报告两例新生儿，广泛的皮疹由分散的丘疹组成，丘疹演化为水泡、脓疱疹、结痂和溃疡。这些伤口在两周的时间里愈合了，留下了疤痕。组织病理学显示三个主要特征--组织细胞肉芽肿、中性粒细胞渗入和通过毛囊经皮下清除退化的胶原和碎片。两名患者均患有先天性免疫缺陷。新生儿的这种皮肤状况，具有明显的临床和组织病理学特征，是免疫缺陷的一种表现，以前没有描述过。
We report two newborns with a widespread cutaneous eruption consisting of discrete papules which evolved into vesicles, pustules, crusts, and ulcers. These healed over a 2-week period with scarring. Histopathology showed three main features-histiocytic granulomas, neutrophilic infiltration, and transepidermal elimination of degenerated collagen and debris through hair follicles. Both patients had congenital immunodeficiency. This skin condition of the newborn, with distinct clinical and histopathologic features, is a manifestation of immunodeficiency that has not been previously described.