A targeted extracellular approach for recording long-term firing patterns of excitable cells: A practical guide.
A targeted extracellular approach for recording long-term firing patterns of excitable cells: A practical guide.
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DOI：
10.1251/bpo46
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发表时间：
2003-02-17
影响因子：
6.4
通讯作者：
Moenter, Suzanne M.
中科院分区：
文献类型：
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作者：
Nunemaker, Craig S.;DeFazio, R. Anthony;Moenter, Suzanne M.
许多内分泌和神经系统中的可兴奋细胞表现出以几分钟为周期的节律。为了观察代表这些节律输出的放电模式，需要一种记录技术，这种技术可以在不影响细胞行为的情况下监测几个小时的电生理活动。靶向细胞外方法（也称为松散补片）实现了这一目标。因为低阻力密封(
Excitable cells in many endocrine and neuronal systems display rhythms with periodicities on the order of many minutes. To observe firing patterns that represent the output of these rhythms requires a recording technique that can monitor electrophysiological activity for several hours without affecting cell behavior. A targeted extracellular approach (also known as loose-patch) accomplishes this objective. Because low resistance seals (