Metoclopramide: A Safe Alternative to Domperidone? A Case Report on Severe Cardiac Adverse Effects in an Older Patient.
Metoclopramide: A Safe Alternative to Domperidone? A Case Report on Severe Cardiac Adverse Effects in an Older Patient.
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DOI：
10.1007/s40800-018-0090-3
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发表时间：
2018-08-07
期刊：
影响因子：
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通讯作者：
Bootsma JEM
中科院分区：
文献类型：
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作者：
Sijtsma LC;Keijsers CJPW;Kerckhoffs APM;Agema WRP;Bootsma JEM
外周抗多巴胺能药物经常用于治疗恶心。然而，多潘立酮因其严重的心脏副作用而臭名昭著。甲氧氯普胺被认为是一种相对安全的替代品，因为长期以来人们认为它对心血管的不良反应不太明显。我们介绍了一名老年患者，在接受静脉注射甲氧氯普胺后不久出现严重心动过缓和低血压。文献中并不经常描述甲氧氯普胺对老年人的心脏不良反应，尤其是没有重大心脏病史的患者。我们建议老年患者静脉注射甲氧氯普胺时要谨慎。
Peripheral antidopaminergic medication is frequently prescribed to treat nausea. However, domperidone is ill-famed for its severe cardiac adverse effects. Metoclopramide has been suggested as a relatively safe alternative because it has long been considered to have less significant cardiovascular adverse effects. We present an older patient who developed severe bradycardia and hypotension shortly after receiving intravenous metoclopramide. Cardiac adverse effects of metoclopramide in elderly are not frequently described in the literature, especially not in patients without a major history of cardiac disease. We recommend caution with intravenous administered metoclopramide in older patients.