EFFECTS OF PHENCYCLIDINE, KETAMINE AND MDMA ON COMPLEX OPERANT-BEHAVIOR IN MONKEYS
EFFECTS OF PHENCYCLIDINE, KETAMINE AND MDMA ON COMPLEX OPERANT-BEHAVIOR IN MONKEYS
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DOI：
10.1016/0091-3057(87)90136-5
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发表时间：
1987-02-01
影响因子：
3.6
通讯作者：
MASTROPAOLO, J
中科院分区：
文献类型：
--
作者：
THOMPSON, DM;WINSAUER, PJ;MASTROPAOLO, J
在多重时间表的一个组成部分中，帕塔猴通过在存在四个数字的情况下对三个杠杆进行顺序响应，在每次会话中获得不同的四响应链（获得）。在另一个组件中，每个会话（性能）的四响应链都是相同的。每个组件中的反应链都是通过固定比例时间表下的食物呈现来维持的。 IM 给药后，苯环己哌啶、氯胺酮和 MDMA（3,4-亚甲二氧基甲基苯丙胺或“摇头丸”）在两个方案组成部分中均产生与剂量相关的总体反应率下降，尽管氯胺酮和 MDMA 的效力（以 mg/kg 为基础）不如苯环己哌啶。在每种药物的高剂量下，总体反应率显着下降主要是由于长时间的初始暂停。氯胺酮与苯环己哌啶相似，在两个时间表组成部分中产生剂量相关的百分比误差增加，但氯胺酮的最大误差增加效应要小得多。这种数量上的差异似乎与氯胺酮对准确性的影响持续时间较短有关。与苯环己哌啶和氯胺酮不同，MDMA 对采集或性能的准确性没有影响。结果表明，MDMA 对复杂操作行为的干扰程度低于苯环己哌啶类药物。
In one component of a multiple schedule, patas monkeys acquired a different four-response chain each session by responding sequentially on three levers in the presence of four numerals (acquisition). In the other component, the four-response chain was the same each session (performance). The response chain in each component was maintained by food presentation under a fixed-ratio schedule. After IM administration, phencyclidine, ketamine, and MDMA (3,4-methylenedioxymethamphetamine or "ecstasy") each produced dose-related decreases in overall response rate in both schedule components, though ketamine and MDMA were less potent (on a mg/kg basis) than phencyclidine. At high doses of each drug, the marked decrease in overall response rate was due primarily to a long initial pause. Ketamine was similar to phencyclidine in producing dose-related increases in percent errors in both schedule components, but the maximal error-increasing effect was considerably smaller with ketamine. This quantitative difference appeared to be related to the shorter duration of ketamine''s effects on accuracy. Unlike phencyclidine and ketamine, MDMA had no effect on accuracy in either acquisition or performance. The results indicate that MDMA disrupts complex operant behavior to a lesser extent than phencyclidine-type drugs.