Localization of Apoptosis (Programmed Cell Death) in Mice by Administration of Lipopolysaccharide

Localization of Apoptosis (Programmed Cell Death) in Mice by Administration of Lipopolysaccharide
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通过给予脂多糖来定位小鼠细胞凋亡(程序性细胞死亡)

DOI:
10.1111/j.1348-0421.1994.tb01838.x
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发表时间:
1994
影响因子:
2.6
通讯作者:
T. Yokochi
T. Yokochi
中科院分区:
医学4区
文献类型:
--
作者:
Xian;A. Morikawa;Kazuko Takahashi;G. Jiang;Y. Kato;T. Sugiyama;M. Kawai;M. Fukada;T. Yokochi

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应用DNA片段原位特异性标记技术,研究了脂多糖对小鼠凋亡细胞的定位作用。该方法清楚地染色了胸腺皮质的胸腺细胞核。骨髓和脾脏中的细胞核也呈阳性染色。这表明胸腺中的皮质是LPS诱导的程序性细胞死亡发生的地方。
Localization of apoptotic cells by administration of lipopolysaccharide into mice was studied by using the in situ specific labeling of fragmented DNA. This method clearly stained the nuclei of thymocytes at the cortex of the thymus. The nuclei of cells in the bone marrow and in the spleen were also positively stained. It was suggested that the cortex in the thymus is where the LPS‐induced programmed cell death occurs.
DOI: 10.1016/s0065-2776(08)60822-6
发表时间: 1991
影响因子: --
作者:
J. Cohen
通讯作者: J. Cohen