Dietary intake and plasma metabolomic analysis of polyunsaturated fatty acids in bipolar subjects reveal dysregulation of linoleic acid metabolism
Dietary intake and plasma metabolomic analysis of polyunsaturated fatty acids in bipolar subjects reveal dysregulation of linoleic acid metabolism
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DOI：
10.1016/j.jpsychires.2014.06.001
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发表时间：
2014-10-01
影响因子：
4.8
通讯作者：
McInnis, Melvin G.
中科院分区：
文献类型：
--
作者：
Evans, Simon J.;Ringrose, Rachel N.;McInnis, Melvin G.
多不饱和脂肪酸(PUFA)与情绪障碍的风险有关。这提出了一个假设，即患者和未受影响的健康对照组之间的代谢差异与原发病有关，或者是药物使用或饮食摄入的次要因素。然而，饮食控制或补充剂研究表明，改善心理健康结果的结果是模棱两可的。这项研究调查了与PUFA代谢相关的饮食模式和代谢概况，将双相I型患者与非精神病对照组进行了比较。我们收集了7天的饮食记录，并对饮食记录后立即收集的空腹血浆进行了代谢分析。经年龄、性别和能量摄入量调整的回归分析发现，双相个体的硒和多不饱和脂肪酸的摄入量显著减少，包括二十碳五烯酸(EPA)(n-3)、二十二碳六烯酸(DHA)(n-3)、花生四烯酸(AA)(n-6)和二十二碳五烯酸(DPA)(n-3/n-6混合)；而饱和脂肪、二十碳六烯酸和二十二碳五烯酸的摄入量显著增加。对来自血浆样本的代谢数据进行回归分析，校正了年龄、性别、体重指数、精神药物使用和饮食多不饱和脂肪酸摄入量，发现双相个体减少了n-6的主要过氧化产物13S-HpODE、亚油酸(LA)、LA的延伸产物二十碳二烯酸(EDA)；减少了由n-6多不饱和脂肪酸合成的前列腺素G2、F2α和EL；以及减少了EPA。在Bonferroni校正后，这些观察结果仍然显着或接近显着，并且与双相和对照个体之间在多不饱和脂肪酸代谢方面的代谢差异一致。这些发现表明，旨在纠正这些代谢差异的特定饮食干预措施可能会影响双相情感障碍患者的健康结果。(C)2014爱思唯尔有限公司。保留所有权利。
Polyunsaturated fatty acids (PUFA) profiles associate with risk for mood disorders. This poses the hypothesis of metabolic differences between patients and unaffected healthy controls that relate to the primary illness or are secondary to medication use or dietary intake. However, dietary manipulation or supplementation studies show equivocal results improving mental health outcomes. This study investigates dietary patterns and metabolic profiles relevant to PUFA metabolism, in bipolar I individuals compared to non-psychiatric controls. We collected seven-day diet records and performed metabolomic analysis of fasted plasma collected immediately after diet recording. Regression analyses adjusted for age, gender and energy intake found that bipolar individuals had significantly lower intake of selenium and PUFAs, including eicosapentaenoic acid (EPA) (n-3), docosahexaenoic acid (DHA) (n-3), arachidonic acid (AA) (n-6) and docosapentaenoic acid (DPA) (n-3/n-6 mix); and significantly increased intake of the saturated fats, eicosanoic and docosanoic acid. Regression analysis of metabolomic data derived from plasma samples, correcting for age, gender, BMI, psychiatric medication use and dietary PUFA intake, revealed that bipolar individuals had reduced 13S-HpODE, a major peroxidation product of the n-6, linoleic acid (LA), reduced eicosadienoic acid (EDA), an elongation product of LA; reduced prostaglandins G2, F2 alpha and El, synthesized from n-6 PUFA; and reduced EPA. These observations remained significant or near significant after Bonferroni correction and are consistent with metabolic variances between bipolar and control individuals with regard to PUFA metabolism. These findings suggest that specific dietary interventions aimed towards correcting these metabolic disparities may impact health outcomes for individuals with bipolar disorder. (C) 2014 Elsevier Ltd. All rights reserved.