Evidence for a putative bipolar disorder locus on 2p13-16 and other potential loci on 4q31, 7q34, 8q13, 9q31, 10q21-24, 13q32, 14q21 and 17q11-12
Evidence for a putative bipolar disorder locus on 2p13-16 and other potential loci on 4q31, 7q34, 8q13, 9q31, 10q21-24, 13q32, 14q21 and 17q11-12
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DOI：
10.1038/sj.mp.4001254
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发表时间：
2003-01-01
影响因子：
11
通讯作者：
Baron, M
中科院分区：
文献类型：
--
作者：
Liu, J;Juo, SH;Baron, M
双相情感障碍(BP)是一种以极端情绪波动为特征的严重而常见的精神障碍。家庭、双胞胎和收养研究有力地支持了遗传因素。遗传模式是复杂的，可能涉及多个尚未确定的基因。为了确定易感基因座，我们对迄今收集到的最大的、特征良好的家系样本之一(40个家系中的373个个体)进行了343个微卫星标记的全基因组扫描。为了增加检测连锁的能力，扫描统计被用来检查基于相邻染色体座位证据的优势(LOD)得分的对数。这一分析产生了显著的连锁证据(全基因组P
Bipolar disorder (BP) is a severe and common psychiatric disorder characterized by extreme mood swings. Family, twin and adoption studies strongly support a genetic component. The mode of inheritance is complex and likely involves multiple, as yet unidentified genes. To identify susceptibility loci, we conducted a genome-wide scan with 343 microsatellite markers in one of the largest, well-characterized pedigree samples assembled to date (373 individuals in 40 pedigrees). To increase power to detect linkage, scan statistics were used to examine the logarithm of odds (lod) scores based on evidence at adjacent chromosomal loci. This analysis yielded significant evidence of linkage (genome-wide P