THE AKR THYMIC ANTIGEN AND ITS DISTRIBUTION IN LEUKEMIAS AND NERVOUS TISSUES.
THE AKR THYMIC ANTIGEN AND ITS DISTRIBUTION IN LEUKEMIAS AND NERVOUS TISSUES.
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DOI：
10.1084/jem.120.3.413
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发表时间：
1964-09-01
影响因子：
15.3
通讯作者：
ALLEN, J M
中科院分区：
文献类型：
--
作者：
REIF, A E;ALLEN, J M
本文报道了胸腺和非胸腺来源的AKR细胞之间明显的血清学分化：这两种细胞在抗原性上是截然不同的。在新生小鼠中，AKR胸腺抗原仅在胸腺中发现高浓度。在成年小鼠中，这种抗原在胸腺、所有神经组织测试和一些白血病中都存在高水平。在淋巴结淋巴细胞、脾淋巴细胞、阑尾、肺和某些其他非胸腺来源的白血病中，它的水平要低得多。AKR胸腺抗原在RF小鼠胸腺和神经组织中呈高水平表达，而在其他16个品系小鼠胸腺细胞中不表达。这16株病毒具有C3HeB/Fe胸腺抗原。该抗原在新生儿和成人组织中的分布与AKR小鼠胸腺抗原的分布相似。没有发现任何例外情况。这些结果是通过免疫细胞溶解和一种定量处理吸收实验数据的新方法获得的。
A clear-cut serological differentiation between AKR lymphocytes of thymic and non-thymic origin is reported: these two cell types are antigenically distinct. In newborn mice, the AKR thymic antigen was found at a high concentration only in thymus. In adult mice, the antigen was present at a high level in thymus, all nervous tissues tested, and some leukemias. It was present at much lower levels in lymph node lymphocytes, splenic lymphocytes, appendix, lung, and certain other leukemias, which appeared to be of non-thymic origin. The AKR thymic antigen was present at a high level in thymus and nervous tissues of RF mice, but was absent from thymocytes of sixteen other mouse strains. These sixteen strains possessed the C3HeB/Fe thymic antigen. The distribution of this antigen in neonatal and adult tissues of the strains tested was similar to that of the AKR thymic antigen in AKR mice. No exceptions were found. These results were obtained by use of immune cytolysis, and of a new method for the quantitative treatment of data from absorption experiments.