Association of anti-Helicobacter pylori neutrophil-activating protein antibody response with anti-aquaporin-4 autoimmunity in Japanese patients with multiple sclerosis and neuromyelitis optica
Association of anti-Helicobacter pylori neutrophil-activating protein antibody response with anti-aquaporin-4 autoimmunity in Japanese patients with multiple sclerosis and neuromyelitis optica
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DOI：
10.1177/1352458509348961
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发表时间：
2009-12-01
影响因子：
5.8
通讯作者：
Kira, Jun-ichi
中科院分区：
文献类型：
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作者：
Li, Wei;Minohara, Motozumi;Kira, Jun-ichi
亚洲人的多发性硬化症 (MS) 有两种不同的亚型：视脊髓型 (OSMS) 和传统型 (CMS)。 OSMS 与视神经脊髓炎 (NMO) 具有相似的特征，一半的 OSMS 患者具有 NMO-免疫球蛋白 G (IgG)/抗水通道蛋白 4 (AQP4) 抗体。我们报告说，CMS 患者中幽门螺杆菌 (H. pylori) 感染的发生率明显低于对照组。为了揭示日本多发性硬化症患者对幽门螺杆菌中性粒细胞激活蛋白（HP-NAP）的免疫反应，根据抗 AQP4 抗体状态，对 162 名多发性硬化症患者、37 名其他炎症性神经系统疾病（OIND）患者和 85 名健康受试者的血清进行了抗幽门螺杆菌抗体检测。通过酶免疫分析检测幽门螺杆菌抗体、抗 HPNAP 抗体和髓过氧化物酶 (MPO)。抗AQP4抗体阳性MS/NMO (AQP4+ /MS)患者的幽门螺杆菌血清阳性率(19/27, 70.4%)显着高于抗AQP4抗体阴性CMS (AQP4- /CMS)患者(22/83, 26.5%)。在幽门螺杆菌感染的个体中，抗 HP-NAP 抗体在 AQP4 + /MS 和 AQP4- /OSMS 患者中比健康受试者更常见（36.8%、34.6% 对 2.8%）。在AQP4+/MS患者中，抗HP-NAP抗体水平与最终Kurtzke扩展残疾状态量表评分呈显着正相关，抗HP-NAP抗体阳性患者的MPO水平高于抗HP-NAP抗体阴性患者。因此，HP-NAP可能与MS/NMO患者抗AQP4抗体相关的神经损伤的病理学有关。
There are two distinct subtypes of multiple sclerosis (MS) in Asians: opticospinal (OSMS) and conventional (CMS). OSMS has similar features to neuromyelitis optica (NMO) and half of OSMS patients have the NMO-Immunoglobulin G (IgG)/anti-aquaporin-4 (AQP4) antibody. We reported that Helicobacter pylori (H. pylori) infection was significantly less common in CMS patients than controls. To reveal the immune responses to the H. pylori neutrophil-activating protein (HP-NAP) in Japanese MS patients, according to anti-AQP4 antibody status, sera from 162 MS patients, 37 patients with other inflammatory neurological diseases (OIND), and 85 healthy subjects were assayed for anti-H. pylori antibodies, anti-HPNAP antibodies, and myeloperoxidase (MPO) by enzyme immunoassays. H. pylori seropositivity rates were significantly higher in anti-AQP4 antibody-positive MS/NMO (AQP4+ /MS) patients (19/27, 70.4%) than anti-AQP4 antibody-negative CMS (AQP4- /CMS) patients (22/83, 26.5%). Among H. pylori-infected individuals, the anti-HP-NAP antibody was significantly more common in AQP4 + /MS and AQP4- /OSMS patients than healthy subjects (36.8%, 34.6% versus 2.8%). Among the AQP4+ /MS patients, a significant positive correlation between anti-HP-NAP antibody levels and the final Kurtzke's Expanded Disability Status Scale scores was found, and MPO levels were higher in anti-HP-NAP antibody-positive patients than anti-HP-NAP antibody-negative ones. Therefore, HP-NAP may be associated with the pathology of anti-AQP4 antibody-related neural damage in MS/NMO patients.