Nanowired Bioelectric Interfaces.
Nanowired Bioelectric Interfaces.
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DOI：
10.1021/acs.chemrev.8b00795
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发表时间：
2019-04
期刊：
影响因子：
62.1
通讯作者：
B. Tian;Charles M. Lieber
中科院分区：
文献类型：
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作者：
B. Tian;Charles M. Lieber
生物系统已经进化出生化、电气、机械和遗传网络，以在不同的长度和时间尺度上执行基本功能。高纵横比的生物纳米线，如细菌毛和神经突，在这些网络中和之间调节着许多相互作用和动态平衡。设计用于模拟生物纳米线结构的合成材料也可以包含类似的功能特性，利用这种结构-功能关系在设计生物界面方面已经被证明是卓有成效的。半导体纳米线是一类特别有前途的生物界面合成纳米线，因为(1)它们独特的光学和电学性质，(2)它们高度的合成控制性和通用性。这些特性使各种电子和光子纳米线设备的制造成为可能，允许在生物分子水平到整个器官水平形成定义明确的、功能性的生物电界面。在这篇焦点回顾中，我们首先讨论了半导体纳米线与生物电界面的历史。接下来，我们重点介绍几个重要的内源性生物纳米线，并将它们作为框架来对基于半导体纳米线的生物界面进行分类。在这个框架内，我们然后回顾了半导体纳米线生物电界面的基本原理，并对材料选择和器件设计进行了评论，以形成跨越多个长度尺度的生物界面。最后，我们讨论了未来使用半导体纳米线生物接口可能产生最大影响的领域。
Biological systems have evolved biochemical, electrical, mechanical, and genetic networks to perform essential functions across various length and time scales. High-aspect-ratio biological nanowires, such as bacterial pili and neurites, mediate many of the interactions and homeostasis in and between these networks. Synthetic materials designed to mimic the structure of biological nanowires could also incorporate similar functional properties, and exploiting this structure-function relationship has already proved fruitful in designing biointerfaces. Semiconductor nanowires are a particularly promising class of synthetic nanowires for biointerfaces, given (1) their unique optical and electronic properties and (2) their high degree of synthetic control and versatility. These characteristics enable fabrication of a variety of electronic and photonic nanowire devices, allowing for the formation of well-defined, functional bioelectric interfaces at the biomolecular level to the whole-organ level. In this Focus Review, we first discuss the history of bioelectric interfaces with semiconductor nanowires. We next highlight several important, endogenous biological nanowires and use these as a framework to categorize semiconductor nanowire-based biointerfaces. Within this framework we then review the fundamentals of bioelectric interfaces with semiconductor nanowires and comment on both material choice and device design to form biointerfaces spanning multiple length scales. We conclude with a discussion of areas with the potential for greatest impact using semiconductor nanowire-enabled biointerfaces in the future.