International consensus guidance for management of myasthenia gravis: Executive summary.
International consensus guidance for management of myasthenia gravis: Executive summary.
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DOI：
10.1212/wnl.0000000000002790
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发表时间：
2016-07-26
期刊：
影响因子：
9.9
通讯作者：
Narayanaswami P
中科院分区：
文献类型：
--
作者：
Sanders DB;Wolfe GI;Benatar M;Evoli A;Gilhus NE;Illa I;Kuntz N;Massey JM;Melms A;Murai H;Nicolle M;Palace J;Richman DP;Verschuuren J;Narayanaswami P
为重症肌无力（MG）的管理制定正式的基于共识的指南。2013年10月，美国重症肌无力基金会（Myasthenia Gravis Foundation of America）任命了一个工作组，负责制定MG治疗指南，并召集了一个由15名国际专家组成的小组。兰德公司/加州大学洛杉矶分校的适当性方法被用来制定共识指导声明。对治疗目标、最小表现、缓解、眼部MG、即将发生的危象、危象和难治性MG进行了定义。一个面对面的小组会议，然后确定了7个治疗主题要解决。最初的指导声明是根据文献摘要编写的。通过三轮匿名电子邮件投票，就根据小组意见修改的指导声明达成共识。针对对症和免疫抑制治疗、IV免疫球蛋白和血浆置换、即将发生和明显的肌无力危象的管理、胸腺切除术、青少年MG、与肌肉特异性酪氨酸激酶抗体相关的MG和妊娠期MG制定了指导性声明。这是MG专家的国际正式共识，旨在成为全球MG患者护理临床医生的指南。
To develop formal consensus-based guidance for the management of myasthenia gravis (MG). In October 2013, the Myasthenia Gravis Foundation of America appointed a Task Force to develop treatment guidance for MG, and a panel of 15 international experts was convened. The RAND/UCLA appropriateness methodology was used to develop consensus guidance statements. Definitions were developed for goals of treatment, minimal manifestations, remission, ocular MG, impending crisis, crisis, and refractory MG. An in-person panel meeting then determined 7 treatment topics to be addressed. Initial guidance statements were developed from literature summaries. Three rounds of anonymous e-mail votes were used to attain consensus on guidance statements modified on the basis of panel input. Guidance statements were developed for symptomatic and immunosuppressive treatments, IV immunoglobulin and plasma exchange, management of impending and manifest myasthenic crisis, thymectomy, juvenile MG, MG associated with antibodies to muscle-specific tyrosine kinase, and MG in pregnancy. This is an international formal consensus of MG experts intended to be a guide for clinicians caring for patients with MG worldwide.