Magnitude of sustained multiple risk factors for ischemic heart disease in Japanese employees: a case-control study.
Magnitude of sustained multiple risk factors for ischemic heart disease in Japanese employees: a case-control study.
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日本员工缺血性心脏病持续多重危险因素的严重程度：一项病例对照研究。
DOI：
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Y. Matsuzawa
中科院分区：
文献类型：
--
作者：
Tadashi Nakamura;Y. Tsubono;K. Kameda;T. Funahashi;S. Yamashita;S. Hisamichi;T. Kita;T. Yamamura;Y. Matsuzawa
进行了一项病例对照研究，以阐明缺血性心脏病（IHD）的原因，如急性心肌梗死和心绞痛，在日本员工。在来自31个行业的122，051名工人中，94名IHD患者为研究对象，来自同一部门的191名年龄匹配但未患IHD的人作为对照。与对照组相比，患者组从发病前至少10年开始，体重指数、血压、空腹血糖、血清总胆固醇和血清甘油三酯显著升高，吸烟量和血清尿酸也有升高趋势。在病例组中，适度饮酒者的频率往往较低。心电图显示，与对照组相比，病例组从发病前9年开始心肌缺血的频率就较高，从3年前开始进一步迅速增加。心律失常受试者的频率与对照组相同，直至发作前3年，并从2年前开始迅速增加。从发病前10年开始，病例组中具有多种风险因素（特别是肥胖、高血压、高脂血症和高血糖）的受试者频率始终高于对照组。条件Logistic回归分析表明，有一个以上的危险因素大大增加了风险，特别是，3个或更多的因素组合的相对风险增加到10.56（95%置信区间：3.30-33.78）。这些研究结果表明，在日本员工的IHD发病涉及多种风险的持续时间长，每年的心电图监测作为医学检查的一部分是重要的预后。
A case-control study was performed to clarify the cause of ischemic heart disease (IHD), such as acute myocardial infarction and angina pectoris, in Japanese employees. Among 122,051 workers from 31 industries, 94 cases of IHD were the subjects of the study, and a total of 191 age-matched subjects from the same department, but who did not develop IHD, served as the controls. Compared with the control group, body mass index, blood pressure, fasting plasma glucose, serum total cholesterol and serum triglyceride were significantly higher, and cigarette consumption and serum uric acid also tended to be higher, in the patient group from at least 10 years prior to onset. The frequency of moderate-drinkers tended to be lower in the case group. Electrocardiograms showed that, compared with the control group, the frequency of myocardial ischemia was higher in the case group from 9 years prior to onset and further rapidly increased from 3 years prior. The frequency of subjects with arrhythmia was the same as the control group until 3 years before onset and increased rapidly from 2 years prior. The frequency of subjects with multiple risk factors, particularly obesity, hypertension, hyperlipidemia and hyperglycemia, was consistently higher in the case group compared with the control group from 10 years prior to onset. Conditional logistic regression analysis demonstrated that having more than one risk factor greatly increased the risk; in particular, the combination of 3 or more factors increased the relative risk to 10.56 (95% confidence interval: 3.30-33.78). These findings suggest that a long duration of multiple risks is involved in the onset of IHD in Japanese employees, and that annual ECG monitoring as part of the medical examination was important in the prognosis.
影响因子：
2.9
作者：
BLAUSTEIN, JD;WADE, GN
通讯作者：
WADE, GN