Long lives for homozygous trembler mutant mice despite virtual absence of peripheral nerve myelin.
Long lives for homozygous trembler mutant mice despite virtual absence of peripheral nerve myelin.
复制标题
尽管实际上缺乏周围神经髓磷脂，但纯合颤抖突变小鼠的寿命却很长。
DOI：
10.1126/science.3388045
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Sidman,RL
中科院分区：
文献类型：
--
作者：
Henry,EW;Sidman,RL
神经系统的功能依赖于沿神经元轴突的点对点信号交流，而髓鞘的轴突绝缘被认为加速了这种传导。失去先前形成的髓磷脂或缺乏髓磷脂形成可能会造成严重甚至致命的后果。颤栗突变纯合子的小鼠几乎不产生外周神经系统髓磷脂，但却有很长的功能寿命。这一结果对周围神经系统髓磷脂起重要作用的观点提出了质疑，至少在这个物种中是这样。
Nervous system functions are dependent on point-to-point communication of signals along neuronal axons, and axonal insulation by myelin is thought to speed such conduction. Loss of previously formed myelin or lack of myelin formation can have serious, even fatal, consequences. Mice homozygous for the trembler mutation make virtually no peripheral nervous system myelin, yet have long and functional lives. This result calls into question the view that peripheral nervous system myelin plays a vital role, at least in this species.