Intraocular penetration of subconjunctivally administered 14C-fluorouracil in rabbits.
Intraocular penetration of subconjunctivally administered 14C-fluorouracil in rabbits.
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兔结膜下注射 14C-氟尿嘧啶的眼内渗透。
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
A. Ostry
中科院分区：
文献类型：
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作者：
J. Rootman;J. Tisdall;G. Gudauskas;A. Ostry
氟尿嘧啶通过不同的给药途径用于治疗各种肿瘤。易感正常组织的毒性限制了全身剂量，但在这个水平上，眼内组织可能得不到肿瘤抑制浓度。结膜下注射6.25毫克的14C-氟尿嘧啶，剂量为0.5毫升，在测试的12小时内，前房浓度峰值为69.5微克/毫升，玻璃体浓度峰值为10.5微克/毫升。这没有造成可见的眼睛损伤。达到的眼内浓度高于报道的抑制选定肿瘤的浓度。给药总剂量远低于全身毒性水平。
Fluorouracil is given for a variety of neoplasms by various administrative routes. Toxicity of susceptible normal tissue limits systemic dosage, but at this level intraocular tissue may not receive tumor-inhibiting concentrations. Subconjunctival administration of 6.25 mg of 14C-fluorouracil in 0.5-mL dosages resulted in a peak anterior chamber concentration of 69.5 micrograms/mL and a peak vitreous concentration of 10.5 micrograms/mL over the 12 hours tested. This resulted in no visible ocular damage. The intraocular levels achieved were greater than the concentration reported to inhibit selected tumors. The total dosage administered was considerably below the level of systemic toxicity.