Repetition priming of motoneuronal activity in a small motor network: intercellular and intracellular signaling.
Repetition priming of motoneuronal activity in a small motor network: intercellular and intracellular signaling.
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DOI：
10.1523/jneurosci.1287-10.2010
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发表时间：
2010-06-30
期刊：
影响因子：
--
通讯作者：
Weiss KR
中科院分区：
文献类型：
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作者：
Friedman AK;Weiss KR
CPG输出的特性受制于宽调制。先前的神经调节研究主要集中在神经调节剂的即时作用上，即在神经调节剂存在或CPG的神经调节输入活跃时施加的作用。然而，已知当神经调节剂不再存在时，神经调节作用会持续存在。在澳大利亚，刺激神经元CBI-2，激活进食CPG，产生重复启动运动程序。这种启动反应反映在运动神经元放电的增加上。由于CBI-2含有两种神经调节肽，FCAP和CP2，我们假设重复启动可能涉及持续的多肽能神经调节。我们发现这些肽产生类似启动的效应，即它们在运动程序中增加了radula开口（B48）和闭合（B8）运动神经元的放电。B8神经元的重复启动是通过接收CPG的调节性输入来实现的。相比之下，我们目前的研究结果表明，B48的启动可能是通过激活cAMP的途径对其内在特征进行直接的肽能调节来实现的。我们认为，直接启动与间接启动，即依赖于CPG的重复启动可能与单个运动神经元从CPG接收的输入类型有关。我们认为，在由同步兴奋-抑制驱动的运动神经元中，重复启动是间接的，因为它优先通过调制cpg的输出来实现。相反，在由交替兴奋-抑制驱动的运动神经元中，可能优先使用直接调节运动神经元。
The characteristics of CPG outputs are subject to extensive modulation. Previous studies of neuromodulation largely focused on immediate actions of neuromodulators, i.e., actions that were exerted at the time when either neuromodulators were present, or neuromodulatory inputs to the CPG were active. However, neuromodulatory actions are known to persist when neuromodulators are no longer present. In Aplysia, stimulation of neuron CBI-2, which activates the feeding CPG, produces a repetition priming of motor programs. This priming is reflected in an increase of firing of motoneurons. As CBI-2 contains two neuromodulatory peptides, FCAP and CP2, we hypothesized that repetition priming may involve persistent peptidergic neuromodulation. We find that these peptides produce priming-like effects, i.e., they increase the firing of radula opening (B48) and closing (B8) motoneurons during motor programs. showed that repetition priming of neuron B8 is implemented by modulatory inputs that B8 receives from the CPG. In contrast, our current findings indicate that priming of B48 may be implemented by a direct peptidergic modulation of its intrinsic characteristics via a pathway that activates cAMP. We suggest that the direct vs. indirect, i.e., CPG dependent, repetition priming may be related to the type of input that individual motoneurons receive from the CPG. We suggest that in motoneurons that are driven by concurrent excitation-inhibition repetition priming is indirect as it is preferentially implemented via modulation of the output of CPGs. In contrast, in motoneurons that are driven by alternating excitation-inhibition, direct modulation of motoneurons may be preferentially used.