Enantioselective synthesis of 3,4-dihydroisoquinolin-1(2H)-ones by nickel-catalyzed denitrogenative annulation of 1,2,3-benzotriazin-4(3H)-ones with allenes.
Enantioselective synthesis of 3,4-dihydroisoquinolin-1(2H)-ones by nickel-catalyzed denitrogenative annulation of 1,2,3-benzotriazin-4(3H)-ones with allenes.
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DOI：
10.1021/ja909603j
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发表时间：
2010-01
影响因子：
15
通讯作者：
M. Yamauchi;M. Morimoto;T. Miura;M. Murakami
中科院分区：
文献类型：
--
作者：
M. Yamauchi;M. Morimoto;T. Miura;M. Murakami
报道了1，2，3-苯并三氮酮-4(~3H)-酮与烯烃在镍-膦配合物催化下的区域选择性脱氮环化反应，合成了多种取代的3，4-二氢异喹啉-1(2H)-酮。还提供了一个高对映选择性的版本，以及该反应的机理过程的结构证据。
A denitrogenative annulation reaction of 1,2,3-benzotriazin-4(3H)-ones with allenes catalyzed by a nickel-phosphine complex to produce a variety of substituted 3,4-dihydroisoquinolin-1(2H)-ones in a regioselective manner is described. A highly enantioselective version, as well as structural evidence for the mechanistic course of this reaction, is also presented.