Perfusion functional MRI reveals cerebral blood flow pattern under psychological stress
Perfusion functional MRI reveals cerebral blood flow pattern under psychological stress
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DOI：
10.1073/pnas.0503082102
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发表时间：
2005-12-06
影响因子：
11.1
通讯作者：
Detre, JA
中科院分区：
文献类型：
--
作者：
Wang, JJ;Rao, HY;Detre, JA
尽管压力在日常生活中普遍存在，并对幸福、健康和认知产生影响，但人们对日常压力体验的神经基础知之甚少。我们使用一种定量和非侵入性的神经成像技术，动脉自旋标记灌注MRI，测量与轻度到中度应激相关的脑血流量(CBF)变化，该变化与带有绩效监测的心算任务有关。压力的激发通过压力和情绪状态的自我报告以及心率和唾液皮质醇水平的测量来验证。应激任务引起的CBF变化与腹侧右侧前额叶皮质(RPFC)和左侧脑岛/壳核区的主观应激评分呈正相关。在完成任务后，腹侧RPFC、右侧脑岛/壳核和前扣带回呈现持续激活状态，这些被试在算术任务中表现出较高的应激水平。此外，腹侧RPFC和右侧眶前叶皮质的基线CBF变化被发现与接受应激任务引起的唾液皮质醇水平和心率的变化相关。我们进一步证明，观察到的右侧前额叶激活不能归因于伴随应激任务的认知需求增加，而是延伸到与负面情绪相关的神经通路之外。我们的结果提供了神经影像证据，证明心理应激会导致负面情绪和警觉，腹侧RPFC在中枢应激反应中起关键作用。
Despite the prevalence of stress in everyday life and its impact on happiness, health, and cognition, little is known about the neural substrate of the experience of everyday stress in humans. We use a quantitative and noninvasive neuroimaging technique, arterial spin-labeling perfusion MRI, to measure cerebral blood flow (CBF) changes associated with mild to moderate stress induced by a mental arithmetic task with performance monitoring. Elicitation of stress was verified by self-report of stress and emotional state and measures of heart rate and salivary-cortisol level. The change in CBF induced by the stress task was positively correlated with subjective stress rating in the ventral right prefrontal cortex (RPFC) and left insula/putamen area. The ventral RPFC along with right insula/putamen and anterior cingulate showed sustained activation after task completion in subjects reporting a high stress level during arithmetic tasks. Additionally, variations of baseline CBF in the ventral RPFC and right orbitofrontal cortex were found to correlate with changes in salivary-cortisol level and heart rate caused by undergoing stress tasks. We further demonstrated that the observed right prefrontal activation could not be attributed to increased cognitive demand accompanying stress tasks and extended beyond neural pathways associated with negative emotions. Our results provide neuroimaging evidence that psychological stress induces negative emotion and vigilance and that the ventral RPFC plays a key role in the central stress response.