A mechano-chemical model for the passive swelling response of an isolated chondron under osmotic loading
A mechano-chemical model for the passive swelling response of an isolated chondron under osmotic loading
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DOI：
10.1007/s10237-006-0026-1
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发表时间：
2006-06-01
影响因子：
3.5
通讯作者：
Guilak, F
中科院分区：
文献类型：
--
作者：
Haider, MA;Schugart, RC;Guilak, F
软骨是关节软骨中的独特结构，其由软骨细胞及其细胞周基质（PCM）组成，细胞周围的狭窄组织区域由VI型胶原和相对于细胞外基质的高糖胺聚糖浓度区分。我们提出了一个理论的机械力化学模型的被动体积响应下的渗透负荷在一个简单的盐溶液中的平衡。软骨细胞被建模为一个理想的渗透压计和PCM模型制定使用三相混合物理论。一个机械化学软骨模型得到假设的软骨边界是可渗透的水和离子，而软骨细胞膜是选择性地只透水。对于新胡克PCM本构关系的情况下，该模型被用来进行高，低渗透负荷下的细胞和软骨变形的参数分析。结合孤立软骨的渗透负荷实验，模型预测将有助于确定细胞周围的固定电荷密度及其对PCM机械性能的相对贡献。
The chondron is a distinct structure in articular cartilage that consists of the chondrocyte and its pericellular matrix (PCM), a narrow tissue region surrounding the cell that is distinguished by type VI collagen and a high glycosaminoglycan concentration relative to the extracellular matrix. We present a theoretical mechano-chemical model for the passive volumetric response of an isolated chondron under osmotic loading in a simple salt solution at equilibrium. The chondrocyte is modeled as an ideal osmometer and the PCM model is formulated using triphasic mixture theory. A mechano-chemical chondron model is obtained assuming that the chondron boundary is permeable to both water and ions, while the chondrocyte membrane is selectively permeable to only water. For the case of a neo-Hookean PCM constitutive law, the model is used to conduct a parametric analysis of cell and chondron deformation under hyper- and hypo-osmotic loading. In combination with osmotic loading experiments on isolated chondrons, model predictions will aid in determination of pericellular fixed charge density and its relative contribution to PCM mechanical properties.