Towards understanding the lifespan extension by reduced insulin signaling: bioinformatics analysis of DAF-16/FOXO direct targets in Caenorhabditis elegans.
Towards understanding the lifespan extension by reduced insulin signaling: bioinformatics analysis of DAF-16/FOXO direct targets in Caenorhabditis elegans.
复制标题
了解通过减少胰岛素信号传导延长寿命：秀丽隐杆线虫 DAF-16/FOXO 直接靶标的生物信息学分析
DOI：
10.18632/oncotarget.8313
复制
发表时间：
2016-04-12
期刊：
影响因子：
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通讯作者：
Zhang GG
中科院分区：
文献类型：
--
作者：
Li YH;Zhang GG
线虫FOXO转录因子DAF-16是决定衰老和长寿的重要因素。在这项工作中，我们手动管理了FOXODB http://lyh.pkmu.cn/foxodb/，，这是一个FOXO直接靶标数据库。它现在覆盖了208个基因。对109个线虫DAF-16直接靶标的生物信息学分析发现了有趣的结果。(I)DAF-16和转录因子PQM-1共同调节某些靶点。(二)17项指标直接规范寿命。(3)饮食限制导致的寿命延长涉及四个目标。以及(Iv)DAF-16直接靶标可能在寿命调节中发挥全球作用。
DAF-16, the C. elegans FOXO transcription factor, is an important determinant in aging and longevity. In this work, we manually curated FOXODB http://lyh.pkmu.cn/foxodb/, a database of FOXO direct targets. It now covers 208 genes. Bioinformatics analysis on 109 DAF-16 direct targets in C. elegans found interesting results. (i) DAF-16 and transcription factor PQM-1 co-regulate some targets. (ii) Seventeen targets directly regulate lifespan. (iii) Four targets are involved in lifespan extension induced by dietary restriction. And (iv) DAF-16 direct targets might play global roles in lifespan regulation.