VIRUS-INDUCED DIABETES-MELLITUS .4. GENETIC AND ENVIRONMENTAL-FACTORS INFLUENCING DEVELOPMENT OF DIABETES AFTER INFECTION WITH M-VARIANT OF ENCEPHALOMYOCARDITIS VIRUS
VIRUS-INDUCED DIABETES-MELLITUS .4. GENETIC AND ENVIRONMENTAL-FACTORS INFLUENCING DEVELOPMENT OF DIABETES AFTER INFECTION WITH M-VARIANT OF ENCEPHALOMYOCARDITIS VIRUS
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DOI：
10.2337/diabetes.25.3.190
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发表时间：
1976-01-01
期刊：
影响因子：
7.7
通讯作者：
NOTKINS, AL
中科院分区：
文献类型：
--
作者：
ROSS, ME;ONODERA, T;NOTKINS, AL
脑心肌炎病毒 (EMC) 的 M 变体感染胰腺 .β。细胞并导致易感小鼠品系出现糖尿病综合征。在敏感品系和抗药性小鼠品系的 4 个 F1 杂交中，感染后糖尿病的发展作为隐性性状遗传。对 F2 代数据的分析表明，> 1 个基因参与了 EMC 糖尿病的发生。 EMC感染动物的血糖水平异常的严重程度和频率明显受到环境因素的影响。
The M variant of encephalomyocarditis virus (EMC) infects pancreatic .beta. cells and causes the development of a diabetic syndrome in susceptible strains of mice. In 4 F1 crosses of susceptible and resistant strains of mice, the development of diabetes after infection was inherited as a recessive trait. Analysis of the data from the F2 generation indicated that > 1 gene was involved in the development of EMC-diabetes. The severity and frequency of abnormal glucose levels in EMC-infected animals was markedly influenced by environmental factors.