Depression and telomere length: A meta-analysis.
Depression and telomere length: A meta-analysis.
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DOI：
10.1016/j.jad.2015.11.052
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发表时间：
2016-02
影响因子：
6.6
通讯作者：
Tyrka AR
中科院分区：
文献类型：
--
作者：
Ridout KK;Ridout SJ;Price LH;Sen S;Tyrka AR
最近的几项研究调查了端粒长度和抑郁症之间的关系，但结果不一致。这项荟萃分析研究了端粒长度和抑郁症是否相关，并探讨了可能影响这种关联的因素。测量临床显著单相抑郁症受试者端粒长度的研究也包括在内。综合检索策略确定了PubMed、MEDLINE、PsycINFO、Global Health、科克伦图书馆和Web of Science中的研究。使用结构化数据抽象表，并使用先验条件评价研究的纳入或排除。使用连续随机效应模型中的标准化平均差异进行分析。38项研究（N = 34，347）符合入选标准。抑郁症与端粒长度之间的相关性是显著的，科恩d效应量为-0.205（p < 0.0001，I2 = 42%）。抑郁严重程度与端粒长度显著相关（p = 0.03）。修剪和填充分析表明存在发表偏倚（p = 0.003），但在考虑偏倚后，相关性仍然非常显著。亚组分析显示，抑郁症评估工具，端粒测量技术，来源组织和共病的医疗条件显着影响的关系。其他潜在重要的亚组，包括抗抑郁药的使用，尚未进行足够详细或数量的研究，因此未在本荟萃分析中进行讨论。抑郁症与端粒长度之间存在负相关。需要进一步的研究来阐明这种关联背后的潜在因果关系，并阐明抑郁症与应激暴露和衰老的细胞标志物之间的生物学联系。
Several recent studies have investigated the relationship between telomere length and depression with inconsistent results. This meta-analysis examined whether telomere length and depression are associated and explored factors that might affect this association. Studies measuring telomere length in subjects with clinically significant unipolar depression were included. A comprehensive search strategy identified studies in PubMed, MEDLINE, PsycINFO, Global Health, The Cochrane Library, and Web of Science. A structured data abstraction form was used and studies were appraised for inclusion or exclusion using a priori conditions. Analyses were conducted using standardized mean differences in a continuous random effects model. Thirty-eight studies (N = 34,347) met the inclusion criteria. The association between depression and telomere length was significant, with a Cohen's d effect size of -0.205 (p < 0.0001, I2 = 42%). Depression severity significantly associated with telomere length (p = 0.03). Trim and fill analysis indicated the presence of publication bias (p = 0.003), but that the association remained highly significant after accounting for the bias. Subgroup analysis revealed depression assessment tools, telomere measurement techniques, source tissue and comorbid medical conditions significantly affected the relationship. Other potentially important sub-groups, including antidepressant use, have not been investigated in sufficient detail or number yet and thus were not addressed in this meta-analysis. There is a negative association between depression and telomere length. Further studies are needed to clarify potential causality underlying this association and to elucidate the biology linking depression and this cellular marker of stress exposure and aging.