Adventures in Inner Space: Microflow Systems for Practical Organic Synthesis
Adventures in Inner Space: Microflow Systems for Practical Organic Synthesis
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DOI：
10.1002/chin.200817272
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发表时间：
2008-04
期刊：
影响因子：
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通讯作者：
T. Fukuyama;M. Rahman;Masa-aki Sato;I. Ryu
中科院分区：
文献类型：
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作者：
T. Fukuyama;M. Rahman;Masa-aki Sato;I. Ryu
本文概述了我们最近使用各种微反应装置实现实际有机合成的努力。这里是我们在离子液体催化反应、光化学转化和多相加氢反应方面的成就，其中流动状态精确地控制停留时间和产物选择性。1引言2离子液体和微流体系的交叉偶联反应2.1微反应体系中的Sonogashira偶联反应2.2自动化微流生产系统中的Mizoroki-Heck反应2.3离子液体中的羰化反应及其在微流体系中的应用3微流体系中的光反应和自由基反应4微流体系中的气液固三相催化反应5结论
This account presents an overview of our recent endeavors to achieve practical organic syntheses using a variety of microreaction devices. Herein are our achievements in ionic liquid-based catalytic reactions, photochemical transformation, and heterogenous hydrogenation reactions, where flow regime precisely controls residence time and product selectivity. 1 Introduction 2 Cross-Coupling Reactions Using Ionic Liquids and Microflow Systems 2.1 The Sonogashira Coupling Reaction in a Microreaction System 2.2 The Mizoroki-Heck Reaction in an Automated Microflow Production System 2.3 Carbonylation in an Ionic Liquid and Application to a Microflow System 3 Photo- and Radical Reactions in a Microflow System 4 Gas-Liquid-Solid Triphasic Catalytic Reactions in a Microflow System 5 Conclusion