The structure and receptor binding properties of the 1918 influenza hemagglutinin
The structure and receptor binding properties of the 1918 influenza hemagglutinin
复制标题
DOI：
10.1126/science.1093155
复制
发表时间：
2004-03-19
期刊：
影响因子：
56.9
通讯作者：
Skehel, JJ
中科院分区：
文献类型：
--
作者：
Gamblin, SJ;Haire, LF;Skehel, JJ
1918 年流感大流行导致约 2000 万人死亡。这种巨大的影响，加上对新出现的感染的重新兴趣，使得对病毒的表征成为当务之急。受体结合是病毒感染的初始事件，是病毒传播性的主要决定因素，对于流感病毒来说，受体结合是由血凝素 (HA) 膜糖蛋白介导的。我们已经确定了 1918 年病毒的 HA 以及与受体类似物复合的两种密切相关的 HA 的晶体结构。他们解释了 1918 HA 在保留禽类前体 HA 的受体结合位点氨基酸特征的同时，如何能够结合人类受体，以及该病毒如何能够在人群中传播。
The 1918 influenza pandemic resulted in about 20 million deaths. This enormous impact, coupled with renewed interest in emerging infections, makes characterization of the virus involved a priority. Receptor binding, the initial event in virus infection, is a major determinant of virus transmissibility that, for influenza viruses, is mediated by the hemagglutinin ( HA) membrane glycoprotein. We have determined the crystal structures of the HA from the 1918 virus and two closely related HAs in complex with receptor analogs. They explain how the 1918 HA, while retaining receptor binding site amino acids characteristic of an avian precursor HA, is able to bind human receptors and how, as a consequence, the virus was able to spread in the human population.