Structurally defined imidazolium-type ionic oligomers as soluble/solid support for peptide synthesis
Structurally defined imidazolium-type ionic oligomers as soluble/solid support for peptide synthesis
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DOI：
10.1021/ol0708875
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发表时间：
2007-07-05
期刊：
影响因子：
5.2
通讯作者：
Chan, Tak Hang
中科院分区：
文献类型：
--
作者：
He, Xun;Chan, Tak Hang
在多图尺度上合成了结构明确的离子液体型咪唑低聚物。这些咪唑盐已被应用于以克为单位高效合成多肽。寡肽的组装是在均相溶液中进行的，不像固相肽合成那样需要大量的多余试剂和封盖。重要的是，这种方法使有效的肽块偶联成为可能。
Structurally defined ionic liquid-type imidazolium oligomers have been synthesized in multigram scales. These imidazolium salts have been applied to synthesize peptides efficiently in gram scale. The assembly of oligopeptides was conducted in homogeneous solution phase without the need of much excess reagents and capping as in the case of solid-phase peptide synthesis. Importantly, this approach made efficient peptide block couplings possible.