Regional changes of fractional anisotropy with normal aging using Statistical Parametric Mapping (SPM)
Regional changes of fractional anisotropy with normal aging using Statistical Parametric Mapping (SPM)
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DOI：
10.2152/jmi.52.186
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发表时间：
2005-08-01
影响因子：
0.7
通讯作者：
Nishitani, Hiromu
中科院分区：
文献类型：
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作者：
Furutani, Kaori;Harada, Masafumi;Nishitani, Hiromu
目的：已有关于扩散张量成像(DTI)在年龄或疾病相关退化方面的应用的报道。DTI通常采用感兴趣区域(ROI)方法进行评估。在本研究中，我们应用统计参数映射(SPM)的统计方法对正常年龄进行DTI评估，并对两种方法的结果进行比较。在SPM上，张量图像被转化为归一化张量图像。结果：SPM显示老年组基底节区、扣带回等皮质灰质的分数各向异性(FA)值较高，放射冠、内囊、半卵圆中心和穹隆体部FA值较低。结论：SPM方法能清晰显示水弥散各向异性的增龄变化，即使在临床环境下也可以无偏倚地评价水弥散各向异性的变化，而不是ROI测量。
Objective: There has been reports on the usefulness of diffusion tensor imaging (DTI) about age-or disease-related degradation. DTI is generally evaluated by the region of interest (ROI) methodology. In this study, we applied a statistical way using Statistical Parametric Mapping (SPM) to assess normal aging by DTI and compared results of these two methods.Methods: Ten young and ten senior normal volunteers were examined. On SPM, tensor images were changed into normalized tensor images. They were compared between the two groups by t-test.Results: In the senior group, fractional anisotropy (FA) values were higher on the basal ganglia, cingulated gyrus and other cortical gray matter, lower in the corona radiata, internal capsule, centrum semiovale and corpus callosum by using SPM. In the ROI method, the results were almost compatible except in the brain periphery.Conclusions: Aging changes on water diffusion anisotropy was clearly shown by SPM method which would be useful to evaluate change of water diffusion anisotropy without operator bias even in clinical setting instead of ROI measurement.