A behavior-based circuit model of how outcome expectations organize learned behavior in larval Drosophila
A behavior-based circuit model of how outcome expectations organize learned behavior in larval Drosophila
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DOI：
10.1101/lm.2163411
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发表时间：
2011-10-01
影响因子：
2
通讯作者：
Gerber, Bertram
中科院分区：
文献类型：
--
作者：
Schleyer, Michael;Saumweber, Timo;Gerber, Bertram
果蝇幼虫结合了联合收割机一个数字简单的大脑，一个相应的适度的行为复杂性，和一个丰富的工具箱转基因操作的可用性。这使得他们作为一个有吸引力的研究案例时，试图实现一个电路级的行为组织的理解。从一系列的行为实验中，我们提出了一个化学感觉处理回路，气味记忆痕迹的形成，以及行为上表达这些记忆痕迹的“决定”过程。该模型结合了关于先天与条件化学感觉行为的神经元组织的陈述，以及嗅觉和味觉通路在建立过程中的相互作用类型，以及气味记忆痕迹的行为表达。它特别表明，先天嗅觉行为在本质上是反应性的，而条件嗅觉行为被视为追求其结果的行动时，被捕获得更好。它结合了现有的神经解剖学和行为学数据，因此应该是有用的脚手架正在进行的调查幼虫果蝇的化学行为系统。
Drosophila larvae combine a numerically simple brain, a correspondingly moderate behavioral complexity, and the availability of a rich toolbox for transgenic manipulation. This makes them attractive as a study case when trying to achieve a circuit-level understanding of behavior organization. From a series of behavioral experiments, we suggest a circuitry of chemosensory processing, odor-tastant memory trace formation, and the "decision" process to behaviorally express these memory traces-or not. The model incorporates statements about the neuronal organization of innate vs. conditioned chemosensory behavior, and the types of interaction between olfactory and gustatory pathways during the establishment as well as the behavioral expression of odor-tastant memory traces. It in particular suggests that innate olfactory behavior is responsive in nature, whereas conditioned olfactory behavior is captured better when seen as an action in pursuit of its outcome. It incorporates the available neuroanatomical and behavioral data and thus should be useful as scaffold for the ongoing investigations of the chemo-behavioral system in larval Drosophila.